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Sialic acid transporter C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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The sialic acid transporter is expressed on both lysosomes and synaptic vesicles, where it appears to allow export of sialic acid and accumulation of acidic amino acids, respectively [1], driven by proton gradients. In lysosomes, degradation of glycoproteins generates amino acids and sugar residues, which are metabolized further following export from the lysosome.

Transporters

1006
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AST (Sialin / SLC17A5) C Show summary »


Target Id 1006
Nomenclature Sialin
Systematic nomenclature SLC17A5
Common abbreviation AST
Previous and unofficial names membrane glycoprotein HP59 | Sodium/sialic acid cotransporter | ISSD | NSD | SIASD | SLD | proton-coupled sialic acid transporter | solute carrier family 17 (anion/sugar transporter), member 5 | solute carrier family 17 (acidic sugar transporter), member 5 | solute carrier family 17 (anion/sugar transporter)
Genes SLC17A5 (Hs), Slc17a5 (Mm), Slc17a5 (Rn)
Ensembl ID ENSG00000119899 (Hs), ENSMUSG00000049624 (Mm), ENSRNOG00000009330 (Rn)
UniProtKB AC Q9NRA2 (Hs), Q8BN82 (Mm)
Bioparadigms SLC Tables SLC17A5 (Hs)
RESOLUTE SLC17A5 (Hs)
Endogenous substrates
L-glutamic acid (in) [1]
L-lactic acid
L-aspartic acid [1]
gluconate (out)
sialic acid
glucuronic acid
Stoichiometry 1 H+ : 1 sialic acid (out)

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References

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How to cite this family page

Database page citation:

Sialic acid transporter. Accessed on 22/07/2024. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=190.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Mathie AA, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Davies JA et al. (2023) The Concise Guide to PHARMACOLOGY 2023/24: Transporters. Br J Pharmacol. 180 Suppl 2:S374-469.