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Sialic acid transporter C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).


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The sialic acid transporter is expressed on both lysosomes and synaptic vesicles, where it appears to allow export of sialic acid and accumulation of acidic amino acids, respectively [1], driven by proton gradients. In lysosomes, degradation of glycoproteins generates amino acids and sugar residues, which are metabolized further following export from the lysosome.


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AST (Sialin / SLC17A5) C Show summary »

Target Id 1006
Nomenclature Sialin
Systematic nomenclature SLC17A5
Common abbreviation AST
Previous and unofficial names membrane glycoprotein HP59 | Sodium/sialic acid cotransporter | ISSD | NSD | SIASD | SLD | proton-coupled sialic acid transporter | solute carrier family 17 (anion/sugar transporter), member 5 | solute carrier family 17 (acidic sugar transporter), member 5 | solute carrier family 17 (anion/sugar transporter)
Genes SLC17A5 (Hs), Slc17a5 (Mm), Slc17a5 (Rn)
Ensembl ID ENSG00000119899 (Hs), ENSMUSG00000049624 (Mm), ENSRNOG00000009330 (Rn)
UniProtKB AC Q9NRA2 (Hs), Q8BN82 (Mm)
Bioparadigms SLC Tables SLC17A5 (Hs)
Endogenous substrates
L-glutamic acid (in) [1]
L-lactic acid
L-aspartic acid [1]
gluconate (out)
sialic acid
glucuronic acid
Stoichiometry 1 H+ : 1 sialic acid (out)


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How to cite this family page

Database page citation:

Sialic acid transporter. Accessed on 22/07/2024. IUPHAR/BPS Guide to PHARMACOLOGY,

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Mathie AA, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Davies JA et al. (2023) The Concise Guide to PHARMACOLOGY 2023/24: Transporters. Br J Pharmacol. 180 Suppl 2:S374-469.