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Vesicular glutamate transporters (VGLUTs) C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).


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Vesicular glutamate transporters (VGLUTs) allow accumulation of glutamate into synaptic vesicles, as well as secretory vesicles in endocrine tissues. The roles of VGLUTs in kidney and liver are unclear. These transporters appear to utilize the proton gradient and also express a chloride conductance [1].


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VGLUT1 (Vesicular glutamate transporter 1 / SLC17A7) C Show summary »

VGLUT2 (Vesicular glutamate transporter 2 / SLC17A6) C Show summary »

Target Id 1008
Nomenclature Vesicular glutamate transporter 2
Systematic nomenclature SLC17A6
Common abbreviation VGLUT2
Previous and unofficial names DNPI | differentiation-associated Na-dependent inorganic phosphate cotransporter | solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 6 | solute carrier family 17 (vesicular glutamate transporter), member 6 | solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter)
Genes SLC17A6 (Hs), Slc17a6 (Mm), Slc17a6 (Rn)
Ensembl ID ENSG00000091664 (Hs), ENSMUSG00000030500 (Mm), ENSRNOG00000016147 (Rn)
UniProtKB AC Q9P2U8 (Hs), Q8BLE7 (Mm), Q9JI12 (Rn)
Bioparadigms SLC Tables SLC17A6 (Hs)
Endogenous substrates L-glutamic acid > D-glutamic acid
Stoichiometry Unknown

VGLUT3 (Vesicular glutamate transporter 3 / SLC17A8) C Show summary »


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How to cite this family page

Database page citation:

Vesicular glutamate transporters (VGLUTs). Accessed on 04/12/2022. IUPHAR/BPS Guide to PHARMACOLOGY,

Concise Guide to PHARMACOLOGY citation:

Alexander SP, Kelly E, Mathie A, Peters JA, Veale EL et al. (2021) THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: Transporters. Br J Pharmacol. 178 Suppl 1:S412-S513.