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Vesicular glutamate transporters (VGLUTs) C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).


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Vesicular glutamate transporters (VGLUTs) allow accumulation of glutamate into synaptic vesicles, as well as secretory vesicles in endocrine tissues. The roles of VGLUTs in kidney and liver are unclear. These transporters appear to utilize the proton gradient and also express a chloride conductance [1].


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VGLUT1 (Vesicular glutamate transporter 1 / SLC17A7) C Show summary »

VGLUT2 (Vesicular glutamate transporter 2 / SLC17A6) C Show summary »

VGLUT3 (Vesicular glutamate transporter 3 / SLC17A8) C Show summary »

Target Id 1009
Nomenclature Vesicular glutamate transporter 3
Systematic nomenclature SLC17A8
Common abbreviation VGLUT3
Previous and unofficial names DFNA25 | deafness, autosomal dominant 25 | solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 8 | solute carrier family 17 (vesicular glutamate transporter), member 8 | solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter)
Genes SLC17A8 (Hs), Slc17a8 (Mm), Slc17a8 (Rn)
Ensembl ID ENSG00000179520 (Hs), ENSMUSG00000019935 (Mm), ENSRNOG00000007581 (Rn)
UniProtKB AC Q8NDX2 (Hs), Q8BFU8 (Mm), Q7TSF2 (Rn)
Bioparadigms SLC Tables SLC17A8 (Hs)
Endogenous substrates L-glutamic acid > D-glutamic acid
Stoichiometry Unknown


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How to cite this family page

Database page citation:

Vesicular glutamate transporters (VGLUTs). Accessed on 24/09/2023. IUPHAR/BPS Guide to PHARMACOLOGY,

Concise Guide to PHARMACOLOGY citation:

Alexander SP, Kelly E, Mathie A, Peters JA, Veale EL et al. (2021) THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: Transporters. Br J Pharmacol. 178 Suppl 1:S412-S513.