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Organic cation transporters (OCT) C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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Organic cation transporters (OCT) are electrogenic, Na+-independent and reversible.

Transporters

1019
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OCT1 (Organic cation transporter 1 / SLC22A1) C Show summary »


Target Id 1019
Nomenclature Organic cation transporter 1
Systematic nomenclature SLC22A1
Common abbreviation OCT1
Previous and unofficial names Orct1 | organic cation transporter 1 | Solute carrier family 22 member 1 | Lx1 | solute carrier family 22 (organic cation transporter), member 1 | solute carrier family 22 (organic cation transporter)
Genes SLC22A1 (Hs), Slc22a1 (Mm), Slc22a1 (Rn)
Ensembl ID ENSG00000175003 (Hs), ENSMUSG00000023829 (Mm), ENSRNOG00000016337 (Rn)
UniProtKB AC O15245 (Hs), O08966 (Mm), Q63089 (Rn)
Bioparadigms SLC Tables SLC22A1 (Hs)
Endogenous substrates
5-hydroxytryptamine
PGE2
PGF
choline
Substrates
tetraethylammonium
desipramine
MPP+
metformin [6]
aciclovir
Inhibitors
clonidine pKi 6.3 [7]
Stoichiometry Unknown

OCT2 (Organic cation transporter 2 / SLC22A2) C Show summary » More detailed page go icon to follow link

OCT3 (Organic cation transporter 3 / SLC22A3) C Show summary »

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Further reading

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References

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NC-IUPHAR subcommittee and family contributors

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How to cite this family page

Database page citation (select format):

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Kelly E, Mathie A, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Davies JA; CGTP Collaborators. (2019) The Concise Guide to PHARMACOLOGY 2019/20: Transporters. Br J Pharmacol. 176 Issue S1: S397-S493.