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SLC23 family of ascorbic acid transporters C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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Predicted to be 12 TM segment proteins, members of this family transport the reduced form of ascorbic acid (while the oxidized form may be handled by members of the SLC2 family (GLUT1/SLC2A1, GLUT3/SLC2A3 and GLUT4/SLC2A4). Phloretin is considered a non-selective inhibitor of these transporters, with an affinity in the micromolar range [1].

Transporters

1041
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SVCT1 (Sodium-dependent vitamin C transporter 1 / SLC23A1) C Show summary »


Target Id 1041
Nomenclature Sodium-dependent vitamin C transporter 1
Systematic nomenclature SLC23A1
Common abbreviation SVCT1
Previous and unofficial names Yolk sac permease-like molecule 3 | SLC23A2 | YSPL3 | solute carrier family 23 (nucleobase transporters), member 2 | Na(+)/L-ascorbic acid transporter 1 | sodium-coupled ascorbic acid transporter 1 | solute carrier family 23 (nucleobase transporters), member 1 | solute carrier family 23 (ascorbic acid transporter), member 1 | solute carrier family 23 (nucleobase transporters)
Genes SLC23A1 (Hs), Slc23a1 (Mm), Slc23a1 (Rn)
Ensembl ID ENSG00000170482 (Hs), ENSMUSG00000024354 (Mm), ENSRNOG00000019938 (Rn)
UniProtKB AC Q9UHI7 (Hs), Q9Z2J0 (Mm), Q9WTW7 (Rn)
Bioparadigms SLC Tables SLC23A1 (Hs)
Endogenous substrates L-ascorbic acid > D-ascorbic acid > dehydroascorbic acid  [3]
Inhibitors
phloretin pKi 4.2 [3]
Labelled ligands
[14C]ascorbic acid (Binding) [2]
Stoichiometry 2 Na+: 1 ascorbic acid (in) [3]

SVCT2 (Sodium-dependent vitamin C transporter 2 / SLC23A2) C Show summary »

SVCT3 (Sodium-dependent vitamin C transporter 3 / SLC23A3) C Show summary »

SNBT1 (Sodium-dependent nucleobase transporter / SLC23A4) C Show summary »

Further reading

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References

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NC-IUPHAR subcommittee and family contributors

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How to cite this family page

Database page citation (select format):

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Kelly E, Mathie A, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Davies JA; CGTP Collaborators. (2019) The Concise Guide to PHARMACOLOGY 2019/20: Transporters. Br J Pharmacol. 176 Issue S1: S397-S493.