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SLC23 family of ascorbic acid transporters C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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Predicted to be 12 TM segment proteins, members of this family transport the reduced form of ascorbic acid (while the oxidized form may be handled by members of the SLC2 family (GLUT1/SLC2A1, GLUT3/SLC2A3 and GLUT4/SLC2A4). Phloretin is considered a non-selective inhibitor of these transporters, with an affinity in the micromolar range [1].

Transporters

1044
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SVCT1 (Sodium-dependent vitamin C transporter 1 / SLC23A1) C Show summary »

SVCT2 (Sodium-dependent vitamin C transporter 2 / SLC23A2) C Show summary »

SVCT3 (Sodium-dependent vitamin C transporter 3 / SLC23A3) C Show summary »

SNBT1 (Sodium-dependent nucleobase transporter / SLC23A4) C Show summary »


Target Id 1044
Nomenclature Sodium-dependent nucleobase transporter
Systematic nomenclature SLC23A4
Common abbreviation SNBT1
Previous and unofficial names solute carrier family 23 (nucleobase transporters), member 4 | solute carrier family 23 (nucleobase transporters), member 4, pseudogene | similar to Solute carrier family 23, member 2 (Sodium-dependent vitamin C transporter 2) | similar to Solute carrier family 23 | 2010107G12Rik | RIKEN cDNA 2010107G12 gene
Genes SLC23A4P (Hs), Slc23a4 (Mm), RGD1565367 (Rn)
Ensembl ID ENSMUSG00000029847 (Mm), ENSRNOG00000026919 (Rn)
Endogenous substrates uracil > thymine > guanine, hypoxanthine > xanthine, uridine  [4]
Substrates
5-fluorouracil [4]
Stoichiometry 1 Na+ : 1 uracil (in) [4]
Comment SLC23A4/SNBT1 is found in rodents and non-human primates, but the sequence is truncated in the human genome and named as a pseudogene, SLC23A4P

Further reading

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References

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NC-IUPHAR subcommittee and family contributors

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How to cite this family page

Database page citation (select format):

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Kelly E, Mathie A, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Davies JA; CGTP Collaborators. (2019) The Concise Guide to PHARMACOLOGY 2019/20: Transporters. Br J Pharmacol. 176 Issue S1: S397-S493.