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SLC36 family of proton-coupled amino acid transporters C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).


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Members of the SLC36 family of proton-coupled amino acid transporters are involved in membrane transport of amino acids and derivatives [28-29]. The four transporters show variable tissue expression patterns and are expressed in various cell types at the plasma-membrane and in intracellular organelles. PAT1 is expressed at the luminal surface of the small intestine and absorbs amino acids and derivatives [4]. In lysosomes, PAT1 functions as an efflux mechanism for amino acids produced during intralysosomal proteolysis [2,25]. PAT2 is expressed at the apical membrane of the renal proximal tubule [7] and at the plasma-membrane in brown/beige adipocytes [30]. PAT1 and PAT4 are involved in regulation of the mTORC1 pathway [11,27]. More comprehensive lists of substrates can be found within the reviews under Further Reading and in the references [3].


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PAT1 (Proton-coupled Amino acid Transporter 1 / SLC36A1) C Show summary »

PAT2 (Proton-coupled Amino acid Transporter 2 / SLC36A2) C Show summary »

PAT3 (Proton-coupled Amino acid Transporter 3 / SLC36A3) C Show summary »

PAT4 (Proton-coupled Amino acid Transporter 4 / SLC36A4) C Show summary »

Target Id 1164
Nomenclature Proton-coupled Amino acid Transporter 4
Systematic nomenclature SLC36A4
Common abbreviation PAT4
Previous and unofficial names LYAAT-2 | solute carrier family 36 (proton/amino acid symporter), member 4 | solute carrier family 36 (proton/amino acid symporter)
Genes SLC36A4 (Hs), Slc36a4 (Mm), Slc36a4 (Rn)
Ensembl ID ENSG00000180773 (Hs), ENSMUSG00000043885 (Mm), ENSRNOG00000011455 (Rn)
UniProtKB AC Q6YBV0 (Hs), Q8CH36 (Mm)
Bioparadigms SLC Tables SLC36A4 (Hs)
Endogenous substrates
L-tryptophan [22]
L-proline [22]
Stoichiometry Unknown
Comment PAT4 is not proton-coupled and functions by facilitated diffusion in an electroneutral, Na+-independent, manner [22]. PAT4 is expressed ubiquitously and is predominantly associated with the Golgi [12].. High PAT4 expression is associated with reduced relapse-free survival after colorectal cancer surgery [12].


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Further reading

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NC-IUPHAR subcommittee and family contributors

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How to cite this family page

Database page citation (select format):

Concise Guide to PHARMACOLOGY citation:

Alexander SP, Kelly E, Mathie A, Peters JA, Veale EL et al. (2021) THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: Transporters. Br J Pharmacol. 178 Suppl 1:S412-S513.