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System A-like transporters C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Transporters

1171
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SNAT1 (sodium-coupled neutral amino acid transporter 1 / SLC38A1) C Show summary »

SNAT2 (sodium-coupled neutral amino acid transporter 2 / SLC38A2) C Show summary »

SNAT4 (sodium-coupled neutral amino acid transporter 4 / SLC38A4) C Show summary »


Target Id 1171
Nomenclature sodium-coupled neutral amino acid transporter 4
Systematic nomenclature SLC38A4
Common abbreviation SNAT4
Previous and unofficial names NAT3 | neutral amino acid transporter 3 | N-system amino acid transporter 3 | ATA3 | PAAT | amino acid transport system A3 | amino acid transporter A3 | solute carrier family 38, member 4 | solute carrier family 38
Genes SLC38A4 (Hs), Slc38a4 (Mm), Slc38a4 (Rn)
Ensembl ID ENSG00000139209 (Hs), ENSMUSG00000022464 (Mm), ENSRNOG00000006653 (Rn)
UniProtKB AC Q969I6 (Hs), Q8R1S9 (Mm), Q9EQ25 (Rn)
Bioparadigms SLC Tables SLC38A4 (Hs)
Substrates L-histidine > L-arginine, L-alanine, L-asparagine, L-lysine > glycine, L-glutamine, L-serine, L-proline, L-leucine, L-phenylalanine  [2]
Substrates
MeAIB
Labelled ligands
[3H]glycine
[14C]alanine
[3H]alanine
[14C]glycine
Stoichiometry 1 Na+ : 1 neutral amino acid (in) [2]
Comment Transport of cationic amino acids by SNAT4 was sodium-independent [2].

References

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How to cite this family page

Database page citation:

System A-like transporters. Accessed on 23/10/2021. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=225.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Kelly E, Mathie A, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Davies JA; CGTP Collaborators. (2019) The Concise Guide to PHARMACOLOGY 2019/20: Transporters. Br J Pharmacol. 176 Issue S1: S397-S493.