System N-like transporters | Transporters | IUPHAR/BPS Guide to PHARMACOLOGY

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SLC superfamily of solute carriers
SLC38 family of sodium-dependent neutral amino acid transporters
System N-like transporters

System N-like transporters C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Transporters

1172

SNAT3 (Sodium-coupled neutral amino acid transporter 3 / SLC38A3) C Show summary »« Hide summary

Target Id

1172

Nomenclature

Sodium-coupled neutral amino acid transporter 3

Systematic nomenclature

SLC38A3

Common abbreviation

SNAT3

Previous and unofficial names

SN1 | solute carrier family 38, member 3 | NAT1 | N-system amino acid transporter 1 | solute carrier family 38

Genes

SLC38A3 (Hs), Slc38a3 (Mm), Slc38a3 (Rn)

Ensembl ID

ENSG00000188338 (Hs), ENSMUSG00000010064 (Mm), ENSRNOG00000016827 (Rn)

UniProtKB AC

Q99624 (Hs), Q9DCP2 (Mm), Q9JHZ9 (Rn)

Bioparadigms SLC Tables

SLC38A3 (Hs)

RESOLUTE

SLC38A3 (Hs)

Substrates

L-histidine , L-glutamine > L-asparagine, L-alanine > L-glutamic acid [2]

Substrates

MeAIB

Labelled ligands

[¹⁴C]glutamine

[³H]glutamine

Stoichiometry

1 Na⁺ : 1 amino acid (in) : 1 H⁺ (out) [1]

SNAT5 (Sodium-coupled neutral amino acid transporter 5 / SLC38A5) C Show summary »« Hide summary

References

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1. Bröer A, Albers A, Setiawan I, Edwards RH, Chaudhry FA, Lang F, Wagner CA, Bröer S. (2002) Regulation of the glutamine transporter SN1 by extracellular pH and intracellular sodium ions. J Physiol (Lond.), 539 (Pt 1): 3-14. [PMID:11850497]

2. Fei YJ, Sugawara M, Nakanishi T, Huang W, Wang H, Prasad PD, Leibach FH, Ganapathy V. (2000) Primary structure, genomic organization, and functional and electrogenic characteristics of human system N 1, a Na+- and H+-coupled glutamine transporter. J Biol Chem, 275 (31): 23707-17. [PMID:10823827]

3. Nakanishi T, Sugawara M, Huang W, Martindale RG, Leibach FH, Ganapathy ME, Prasad PD, Ganapathy V. (2001) Structure, function, and tissue expression pattern of human SN2, a subtype of the amino acid transport system N. Biochem Biophys Res Commun, 281 (5): 1343-8. [PMID:11243884]

How to cite this family page

Database page citation:

System N-like transporters. Accessed on 01/07/2025. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=226.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Mathie AA, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Davies JA et al. (2023) The Concise Guide to PHARMACOLOGY 2023/24: Transporters. Br J Pharmacol. 180 Suppl 2:S374-469.