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SLC39 family of metal ion transporters C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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Along with the SLC30 family, SLC39 family members regulate zinc movement in cells. SLC39 metal ion transporters accumulate zinc into the cytosol. Membrane topology modelling suggests the presence of eight TM regions with both termini extracellular or in the lumen of intracellular organelles. The mechanism for zinc transport for many members is unknown but appears to involve co-transport of bicarbonate ions [2-3].

Transporters

1183
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ZIP1 (Zinc transporter 1 / SLC39A1) Show summary »

ZIP2 (Zinc transporter 2 / SLC39A2) Show summary »

ZIP3 (Zinc transporter 3 / SLC39A3) Show summary »

ZIP4 (Zinc transporter 4 / SLC39A4) Show summary »


Target Id 1183
Nomenclature Zinc transporter 4
Systematic nomenclature SLC39A4
Common abbreviation ZIP4
Previous and unofficial names ZRT- and IRT-like protein 4 | solute carrier family 39 member 4 | solute carrier family 39 (zinc transporter), member 4 | solute carrier family 39 (zinc transporter)
Genes SLC39A4 (Hs), Slc39a4 (Mm), Slc39a4 (Rn)
Ensembl ID ENSG00000206288 (Hs), ENSMUSG00000063354 (Mm), ENSRNOG00000014314 (Rn)
UniProtKB AC Q6P5W5 (Hs), Q78IQ7 (Mm), A0JPN2 (Rn)
Bioparadigms SLC Tables SLC39A4 (Hs)

ZIP5 (Zinc transporter 5 / SLC39A5) Show summary »

ZIP6 (Zinc transporter 6 / SLC39A6) Show summary »

ZIP7 (Zinc transporter 7 / SLC39A7) Show summary »

ZIP8 (Zinc transporter 8 / SLC39A8) C Show summary »

ZIP9 (Zinc transporter 9 / SLC39A9) Show summary »

ZIP10 (Zinc transporter 10 / SLC39A10) Show summary »

ZIP11 (Zinc transporter 11 / SLC39A11) Show summary »

ZIP12 (Zinc transporter 12 / SLC39A12) Show summary »

ZIP13 (Zinc transporter 13 / SLC39A13) Show summary »

ZIP14 (Zinc transporter 14 / SLC39A14) C Show summary »

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References

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How to cite this family page

Database page citation:

SLC39 family of metal ion transporters. Accessed on 23/09/2021. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=228.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Kelly E, Mathie A, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Davies JA; CGTP Collaborators. (2019) The Concise Guide to PHARMACOLOGY 2019/20: Transporters. Br J Pharmacol. 176 Issue S1: S397-S493.