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SLC39 family of metal ion transporters C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).


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Along with the SLC30 family, SLC39 family members regulate zinc movement in cells. SLC39 metal ion transporters accumulate zinc into the cytosol. Membrane topology modelling suggests the presence of eight TM regions with both termini extracellular or in the lumen of intracellular organelles. The mechanism for zinc transport for many members is unknown but appears to involve co-transport of bicarbonate ions [2,4].


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ZIP1 (Zinc transporter 1 / SLC39A1) Show summary »

ZIP2 (Zinc transporter 2 / SLC39A2) Show summary »

ZIP3 (Zinc transporter 3 / SLC39A3) Show summary »

ZIP4 (Zinc transporter 4 / SLC39A4) Show summary »

ZIP5 (Zinc transporter 5 / SLC39A5) Show summary »

ZIP6 (Zinc transporter 6 / SLC39A6) Show summary »

Target Id 1185
Nomenclature Zinc transporter 6
Systematic nomenclature SLC39A6
Common abbreviation ZIP6
Previous and unofficial names solute carrier family 39 (metal ion transporter) | Ermelin | LIV1 | LIV-1 | solute carrier family 39 (metal ion transporter), member 6 | solute carrier family 39 (zinc transporter), member 6 | zrt- and Irt-like protein 6
Genes SLC39A6 (Hs), Slc39a6 (Mm), Slc39a6 (Rn)
Ensembl ID ENSG00000141424 (Hs), ENSMUSG00000024270 (Mm), ENSRNOG00000028703 (Rn)
UniProtKB AC Q13433 (Hs), Q8C145 (Mm), Q4V887 (Rn)
Bioparadigms SLC Tables SLC39A6 (Hs)
Comment SLC39A6 (LIV-1) is a novel immuno-oncology drug target. An antibody-drug conjugate coded SGN-LIV1A is a Phase 1 clinical candidate for LIV-1-expressing tumours, in particular for triple negative breast cancers- see NCT03310957.

ZIP7 (Zinc transporter 7 / SLC39A7) Show summary »

ZIP8 (Zinc transporter 8 / SLC39A8) C Show summary »

ZIP9 (Zinc transporter 9 / SLC39A9) Show summary »

ZIP10 (Zinc transporter 10 / SLC39A10) Show summary »

ZIP11 (Zinc transporter 11 / SLC39A11) Show summary »

ZIP12 (Zinc transporter 12 / SLC39A12) Show summary »

ZIP13 (Zinc transporter 13 / SLC39A13) Show summary »

ZIP14 (Zinc transporter 14 / SLC39A14) C Show summary »


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Further reading

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NC-IUPHAR subcommittee and family contributors

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How to cite this family page

Database page citation (select format):

Concise Guide to PHARMACOLOGY citation:

Alexander SP, Kelly E, Mathie A, Peters JA, Veale EL et al. (2021) THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: Transporters. Br J Pharmacol. 178 Suppl 1:S412-S513.