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SLC42 family of Rhesus glycoprotein ammonium transporters C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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Rhesus is commonly defined as a ‘factor’ that determines, in part, blood type, and whether neonates suffer from haemolytic disease of the newborn. These glycoprotein antigens derive from two genes, RHCE (P18577) and RHD (Q02161), expressed on the surface of erythrocytes. On erythrocytes, RhAG associates with these antigens and functions as an ammonium transporter. RhBG and RhBG are non-erythroid related sequences associated with epithelia. Topological modelling suggests the presence of 12TM with cytoplasmic N- and C- termini. The majority of information on these transporters derives from orthologues in yeast, plants and bacteria. More recent evidence points to family members being permeable to carbon dioxide, leading to the term gas channels.

Transporters

1198
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RhAG (Ammonium transporter Rh type A / SLC42A1) C Show summary »


Target Id 1198
Nomenclature Ammonium transporter Rh type A
Systematic nomenclature SLC42A1
Common abbreviation RhAG
Previous and unofficial names CD241 | erythrocyte membrane glycoprotein Rh50 | glycoprotein 50kD | Rh-associated glycoprotein | Rhesus blood group-associated A glycoprotein
Genes RHAG (Hs), Rhag (Mm), Rhag (Rn)
Ensembl ID ENSG00000112077 (Hs), ENSMUSG00000023926 (Mm), ENSRNOG00000034152 (Rn)
UniProtKB AC Q02094 (Hs), Q9QUT0 (Mm), Q7TNK7 (Rn)
Bioparadigms SLC Tables SLC42A1 (Hs)
Substrates
CO2 [1]
NH3 [4]
NH4+ [5]
Labelled ligands
[14C]methylamine (Binding) [2]
Stoichiometry Unknown

RhBG (Ammonium transporter Rh type B / SLC42A2) C Show summary »

RhCG (Ammonium transporter Rh type C / SLC42A3) C Show summary »

Further reading

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References

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How to cite this family page

Database page citation:

SLC42 family of Rhesus glycoprotein ammonium transporters. Accessed on 21/10/2021. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=231.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Kelly E, Mathie A, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Davies JA; CGTP Collaborators. (2019) The Concise Guide to PHARMACOLOGY 2019/20: Transporters. Br J Pharmacol. 176 Issue S1: S397-S493.