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SLC43 family of large neutral amino acid transporters C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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LAT3 (SLC43A1) and LAT4 (SLC43A2) are transporters with system L amino acid transporter activity, along with the structurally and functionally distinct transporters LAT1 and LAT2 that are members of the SLC7 family. LAT3 and LAT4 contain 12 putative TM domains with both N and C termini located intracellularly. They transport neutral amino acids in a manner independent of Na+ and Cl- and with two kinetic components [1-2]. LAT3/SLC43A1 is expressed in human tissues at high levels in the pancreas, liver, skeletal muscle and fetal liver [1] whereas LAT4/SLC43A2 is primarily expressed in the placenta, kidney and peripheral blood leukocytes [2]. SLC43A3 is expressed in vascular endothelial cells [3] but remains to be characterised.

Transporters

1202
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LAT3 (L-type amino acid transporter 3 / SLC43A1) C Show summary »

LAT4 (L-type amino acid transporter 4 / SLC43A2) C Show summary »


Target Id 1202
Nomenclature L-type amino acid transporter 4
Systematic nomenclature SLC43A2
Common abbreviation LAT4
Previous and unofficial names large neutral amino acids transporter small subunit 4 | solute carrier family 43, member 2 | solute carrier family 43 (amino acid system L transporter), member 2 | solute carrier family 43
Genes SLC43A2 (Hs), Slc43a2 (Mm), Slc43a2 (Rn)
Ensembl ID ENSG00000167703 (Hs), ENSMUSG00000038178 (Mm), ENSRNOG00000003835 (Rn)
UniProtKB AC Q8N370 (Hs), Q8CGA3 (Mm)
Bioparadigms SLC Tables SLC43A2 (Hs)
Substrates
L-isoleucine
L-leucine
L-phenylalanine
L-valinol
L-leucinol
L-valine
L-methionine
Stoichiometry Operates by facilitative diffusion

EEG1 (Solute carrier family 43 member 3 / SLC43A3) Show summary »

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Further reading

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References

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How to cite this family page

Database page citation:

SLC43 family of large neutral amino acid transporters. Accessed on 19/10/2021. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=232.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Kelly E, Mathie A, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Davies JA; CGTP Collaborators. (2019) The Concise Guide to PHARMACOLOGY 2019/20: Transporters. Br J Pharmacol. 176 Issue S1: S397-S493.