Top ▲

SLC44 choline transporter-like family C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

Click here for help

« Hide

Members of the choline transporter-like family are encoded by five genes (CTL1-CTL5) with further diversity occurring through alternative splicing of CTL1, 4 and 5 [9]. CTL family members are putative 10TM domain proteins with extracellular termini that mediate Na+-independent transport of choline with an affinity that is intermediate to that of the high affinity choline transporter CHT1 (SLC5A7) and the low affinity organic-cation transporters [OCT1 (SLC22A1) and OCT2 (SLC22A2)] [6]. CLT1 is expressed almost ubiquitously in human tissues [11] and mediates choline transport across the plasma and mitochondrial membranes [5]. Transport of choline by CTL2, which in rodents is expressed as two isoforms (CTL2P1 and CLTP2; [3]) in lung, colon, inner ear and spleen and to a lesser extent in brain, tongue, liver, and kidney, has only recently been demonstrated [3,8]. CTL3-5 remain to be characterized functionally.

Transporters

1204
Click here for help

CTL1 (Choline transporter-like 1 / SLC44A1) C Show summary »


Target Id 1204
Nomenclature Choline transporter-like 1
Systematic nomenclature SLC44A1
Common abbreviation CTL1
Previous and unofficial names CHTL1 | CD92 | solute carrier family 44 member 1 | solute carrier family 44 (choline transporter), member 1 | solute carrier family 44
Genes SLC44A1 (Hs), Slc44a1 (Mm), Slc44a1 (Rn)
Ensembl ID ENSG00000070214 (Hs), ENSMUSG00000028412 (Mm), ENSRNOG00000017846 (Rn)
UniProtKB AC Q8WWI5 (Hs), Q6X893 (Mm), Q8VII6 (Rn)
Bioparadigms SLC Tables SLC44A1 (Hs)
Substrates
choline
Inhibitors
hemicholinium-3 pKi 3.5 – 4.5
Stoichiometry Unknown: uptake enhanced in the absence of extracellular Na+, reduced by membrane depolarization, extracellular acidification and collapse of plasma membrane H+ electrochemical gradient

CTL2 (Choline transporter-like 2 / SLC44A2) Show summary »

CTL3 (Choline transporter-like 3 / SLC44A3) Show summary »

CTL4 (Choline transporter-like 4 / SLC44A4) Show summary »

CTL5 (Choline transporter-like 5 / SLC44A5) Show summary »

Comments

Click here for help

Show »

Further reading

Click here for help

Show »

References

Click here for help

Show »

How to cite this family page

Database page citation:

SLC44 choline transporter-like family. Accessed on 30/11/2021. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=233.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Kelly E, Mathie A, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Davies JA; CGTP Collaborators. (2019) The Concise Guide to PHARMACOLOGY 2019/20: Transporters. Br J Pharmacol. 176 Issue S1: S397-S493.