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SLC47 family of multidrug and toxin extrusion transporters C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).


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Human multidrug and toxin extrusion MATE1 and MATE2-K are H+/organic cation antiporters [1]. They are predominantly expressed in the kidney and play a role in renal tubular secretion of cationic drugs.


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MATE1 (Multidrug and toxin extrusion / SLC47A1) C Show summary »

Target Id 1216
Nomenclature Multidrug and toxin extrusion
Systematic nomenclature SLC47A1
Common abbreviation MATE1
Previous and unofficial names H+/organic cation antiporter variant 1 | H+/organic cation antiporter variant 2 | solute carrier family 47, member 1 | solute carrier family 47 (multidrug and toxin extrusion), member 1 | solute carrier family 47
Genes SLC47A1 (Hs), Slc47a1 (Mm), Slc47a1 (Rn)
Ensembl ID ENSG00000142494 (Hs), ENSMUSG00000010122 (Mm), ENSRNOG00000057404 (Rn)
UniProtKB AC Q96FL8 (Hs), Q8K0H1 (Mm), Q5I0E9 (Rn)
Bioparadigms SLC Tables SLC47A1 (Hs)
Endogenous substrates
creatine [7]
thiamine [7]
quinidine [7]
paraquat [2]
cephradine [7]
cephalexin [7]
cimetidine pKm 3.8 [5,7]
metformin pKm 3.1 [7]
Sub/family-selective inhibitors
pyrimethamine pKi 7.1 [3]
cimetidine pKi 6.0 [9]
Labelled ligands
[14C]metformin [7-8]
[14C]TEA [6,8]

MATE2-K (MATE2 / SLC47A2) C Show summary »


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Further reading

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NC-IUPHAR subcommittee and family contributors

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How to cite this family page

Database page citation (select format):

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Mathie AA, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Davies JA et al. (2023) The Concise Guide to PHARMACOLOGY 2023/24: Transporters. Br J Pharmacol. 180 Suppl 2:S374-469.