Top ▲

SLC47 family of multidrug and toxin extrusion transporters C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).


Click here for help

« Hide

Human multidrug and toxin extrusion MATE1 and MATE2-K are H+/organic cation antiporters [1]. They are predominantly expressed in the kidney and play a role in renal tubular secretion of cationic drugs.


Click here for help

MATE1 (Multidrug and toxin extrusion / SLC47A1) C Show summary »

MATE2-K (MATE2 / SLC47A2) C Show summary »

Target Id 1217
Nomenclature MATE2
Systematic nomenclature SLC47A2
Common abbreviation MATE2-K
Previous and unofficial names MATE2-K | multidrug and toxin extrusion protein 2 | solute carrier family 47, member 2 | solute carrier family 47 (multidrug and toxin extrusion), member 2 | solute carrier family 47
Genes SLC47A2 (Hs), Slc47a2 (Mm), Slc47a2 (Rn)
Ensembl ID ENSG00000180638 (Hs), ENSMUSG00000069855 (Mm), ENSRNOG00000038055 (Rn)
UniProtKB AC Q86VL8 (Hs), Q3V050 (Mm)
Bioparadigms SLC Tables SLC47A2 (Hs)
Endogenous substrates
creatine [7]
thiamine [7]
MPP+ [4]
N1-methylnicotinamide [4]
guanidine [7]
procainamide [4]
aciclovir [7]
cimetidine pKm 3.9 [4,7]
metformin pKm 2.7 [4,7]
Sub/family-selective inhibitors
pyrimethamine pKi 6.3 [3] - Mouse
cimetidine pKi 5.1 [9]
Labelled ligands
[14C]metformin [7]
[14C]TEA [7]


Click here for help

Show »

Further reading

Click here for help

Show »


Click here for help

Show »

NC-IUPHAR subcommittee and family contributors

Show »

How to cite this family page

Database page citation (select format):

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Mathie AA, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Davies JA et al. (2023) The Concise Guide to PHARMACOLOGY 2023/24: Transporters. Br J Pharmacol. 180 Suppl 2:S374-469.