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SLC47 family of multidrug and toxin extrusion transporters C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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These proton:organic cation exchangers are predicted to have 13 TM segments [11] and are suggested to be responsible for excretion of many drugs in the liver and kidneys [1].

Transporters

1217
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MATE1 (Multidrug and toxin extrusion / SLC47A1) C Show summary »

MATE2-K (MATE2 / SLC47A2) C Show summary »


Target Id 1217
Nomenclature MATE2
Systematic nomenclature SLC47A2
Common abbreviation MATE2-K
Previous and unofficial names MATE2-K | multidrug and toxin extrusion protein 2 | solute carrier family 47, member 2 | solute carrier family 47 (multidrug and toxin extrusion), member 2 | solute carrier family 47
Genes SLC47A2 (Hs), Slc47a2 (Mm), Slc47a2 (Rn)
Ensembl ID ENSG00000180638 (Hs), ENSMUSG00000069855 (Mm), ENSRNOG00000038055 (Rn)
UniProtKB AC Q86VL8 (Hs), Q3V050 (Mm)
Bioparadigms SLC Tables SLC47A2 (Hs)
Endogenous substrates
creatine [7]
thiamine [7]
Substrates
MPP+ [4]
N1-methylnicotinamide [4]
guanidine [7]
procainamide [4]
aciclovir [7]
cimetidine pKm 3.9 [4,7]
metformin pKm 2.7 [4,7]
Sub/family-selective inhibitors
pyrimethamine pKi 6.3 [3] - Mouse
cimetidine pKi 5.1 [9]
Labelled ligands
[14C]metformin [7]
[14C]TEA [7]

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Further reading

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References

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NC-IUPHAR subcommittee and family contributors

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How to cite this family page

Database page citation (select format):

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Kelly E, Mathie A, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Davies JA; CGTP Collaborators. (2019) The Concise Guide to PHARMACOLOGY 2019/20: Transporters. Br J Pharmacol. 176 Issue S1: S397-S493.