Dimethylarginine dimethylaminohydrolases | Enzymes | IUPHAR/BPS Guide to PHARMACOLOGY

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L-Arginine turnover
Dimethylarginine dimethylaminohydrolases

Dimethylarginine dimethylaminohydrolases C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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Dimethylarginine dimethylaminohydrolases (DDAH, EC 3.5.3.18) are cytoplasmic enzymes which hydrolyse N^G,N^G-dimethyl-L-arginine to form dimethylamine and L-citrulline.

Enzymes

DDAH1 (N^G,N^G-Dimethylarginine dimethylaminohydrolase 1) C Show summary »« Hide summary

DDAH2 (N^G,N^G-Dimethylarginine dimethylaminohydrolase 2) C Show summary »« Hide summary

Target Id

1248

Nomenclature

N^G,N^G-Dimethylarginine dimethylaminohydrolase 2

Common abbreviation

DDAH2

Previous and unofficial names

Genes

DDAH2 (Hs), Ddah2 (Mm), Ddah2 (Rn)

Ensembl ID

ENSG00000213722 (Hs), ENSMUSG00000007039 (Mm), ENSRNOG00000000842 (Rn)

UniProtKB AC

O95865 (Hs), Q99LD8 (Mm), Q6MG60 (Rn)

EC number

3.5.3.18

References

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How to cite this family page

Database page citation:

Dimethylarginine dimethylaminohydrolases. Accessed on 01/07/2025. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=252.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Mathie AA, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Davies JA et al. (2023) The Concise Guide to PHARMACOLOGY 2023/24: Enzymes. Br J Pharmacol. 180 Suppl 2:S289-373.