CYP1 family | Enzymes | IUPHAR/BPS Guide to PHARMACOLOGY

CYP1 family C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Enzymes

CYP1A1 C Show summary »« Hide summary More detailed page

Target Id

1318

Nomenclature

CYP1A1

Previous and unofficial names

Genes

CYP1A1 (Hs), Cyp1a1 (Mm), Cyp1a1 (Rn)

Ensembl ID

ENSG00000140465 (Hs), ENSMUSG00000032315 (Mm), ENSRNOG00000019500 (Rn)

UniProtKB AC

P04798 (Hs), P00184 (Mm), P00185 (Rn)

EC number

1.14.1.1

Inhibitors

5H3'FPE pIC₅₀ 7.4 [1]

CYP1A2 C Show summary »« Hide summary More detailed page

Target Id

1319

Nomenclature

CYP1A2

Previous and unofficial names

cytochrome P450, subfamily I (aromatic compound-inducible), polypeptide 2 | cytochrome P450 1A2 | Cytochrome P450 subfamily I (aromatic compound-inducible) member A2 (Q42 form d) | cytochrome P450, family 1, subfamily A, polypeptide 2 | cytochrome P450, family 1, subfamily a, polypeptide 2 | cytochrome P450

Genes

CYP1A2 (Hs), Cyp1a2 (Mm), Cyp1a2 (Rn)

Ensembl ID

ENSG00000140505 (Hs), ENSMUSG00000032310 (Mm), ENSRNOG00000016173 (Rn)

UniProtKB AC

P05177 (Hs), P00186 (Mm), P04799 (Rn)

EC number

1.14.1.1

Inhibitors

5H3'FPE pIC₅₀ 6.4 [1]

CYP1B1 C Show summary »« Hide summary More detailed page

Target Id

1320

Nomenclature

CYP1B1

Previous and unofficial names

GLC3A | cytochrome P450, subfamily I (dioxin-inducible), polypeptide 1 (glaucoma 3, primary infantile) | cytochrome P450, subfamily 1B, polypeptide 1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | cytochrome P450, family 1, subfamily b, polypeptide 1 | cytochrome P450

Genes

CYP1B1 (Hs), Cyp1b1 (Mm), Cyp1b1 (Rn)

Ensembl ID

ENSG00000138061 (Hs), ENSMUSG00000024087 (Mm), ENSRNOG00000040287 (Rn)

UniProtKB AC

Q16678 (Hs), Q64429 (Mm), Q64678 (Rn)

EC number

1.14.1.1

Comment

Mutations have been associated with primary congenitial glucoma [2]

References

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How to cite this family page

Database page citation:

CYP1 family. Accessed on 22/02/2019. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=261.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Marrion NV, Peters JA, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Davies JA; CGTP Collaborators. (2017) The Concise Guide to PHARMACOLOGY 2017/18: Enzymes. Br J Pharmacol. 174 Suppl 1: S272-S359.