CYP4 family | Enzymes | IUPHAR/BPS Guide to PHARMACOLOGY

CYP4 family C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Enzymes

CYP4A11 C Show summary »« Hide summary

Target Id

1341

Nomenclature

CYP4A11

Previous and unofficial names

Genes

CYP4A11 (Hs)

Ensembl ID

ENSG00000187048 (Hs)

UniProtKB AC

Q02928 (Hs)

EC number

1.14.14.80

Comment

Converts lauric acid to 12-hydroxylauric acid.

CYP4A22 C Show summary »« Hide summary

Target Id

1342

Nomenclature

CYP4A22

Previous and unofficial names

fatty acid ω-hydroxylase | lauric acid ω-hydroxylase | cytochrome P450, family 4, subfamily A, polypeptide 22

Genes

CYP4A22 (Hs)

Ensembl ID

ENSG00000162365 (Hs)

UniProtKB AC

Q5TCH4 (Hs)

EC number

1.14.14.80

Comment

Reported to be enzymatically inactive [3].

CYP4B1 C Show summary »« Hide summary

Target Id

1343

Nomenclature

CYP4B1

Previous and unofficial names

cytochrome P450 4B1 | cytochrome P450, subfamily 4B, polypeptide 1 | cytochrome P450, family 4, subfamily B, polypeptide 1 | cytochrome P450

Genes

CYP4B1 (Hs), Cyp4b1 (Mm), Cyp4b1 (Rn)

Ensembl ID

ENSG00000142973 (Hs), ENSMUSG00000028713 (Mm), ENSRNOG00000009741 (Rn)

UniProtKB AC

P13584 (Hs), Q64462 (Mm), P15129 (Rn)

EC number

1.14.14.1

CYP4F2 C Show summary »« Hide summary

Target Id

1344

Nomenclature

CYP4F2

Previous and unofficial names

Leukotriene B₄ 20-monooxygenase 1 | leukotriene B₄ ω-hydroxylase 1 | cytochrome P450, family 4, subfamily F, polypeptide 2

Genes

CYP4F2 (Hs)

Ensembl ID

ENSG00000186115 (Hs)

UniProtKB AC

P78329 (Hs)

EC number

1.14.14.78

1.14.14.79

1.14.14.94

Inhibitors

17-octadecynoic acid pK_i 5.9 [8]

Comment

Responsible for ω-hydroxylation of LTB₄, LXB₄ [5], and tocopherols, including vitamin E [9]

CYP4F3 C Show summary »« Hide summary

Target Id

1345

Nomenclature

CYP4F3

Previous and unofficial names

cytochrome P450-LTB-omega | leukotriene-B(4) 20-monooxygenase 2 | leukotriene-B(4) omega-hydroxylase 2 | cytochrome P450, family 4, subfamily F, polypeptide 3

Genes

CYP4F3 (Hs)

Ensembl ID

ENSG00000186529 (Hs)

UniProtKB AC

Q08477 (Hs)

EC number

1.14.14.78

1.14.14.79

1.14.14.94

Comment

Responsible for ω-hydroxylation of LTB₄, LXB₄ [5], and polyunsaturated fatty acids [2,4]

CYP4F8 C Show summary »« Hide summary

Target Id

1346

Nomenclature

CYP4F8

Previous and unofficial names

cytochrome P450, subfamily IVF, polypeptide 8 | cytochrome P450, family 4, subfamily F, polypeptide 8

Genes

CYP4F8 (Hs)

Ensembl ID

ENSG00000186526 (Hs)

UniProtKB AC

P98187 (Hs)

EC number

1.14.14.1

Comment

Converts PGH₂ to 19-hydroxyPGH₂ [1] and 8,9-EET or 11,12-EET to 18-hydroxy-8,9-EET or 18-hydroxy-11,12-EET [7].

CYP4F11 C Show summary »« Hide summary

Target Id

1347

Nomenclature

CYP4F11

Previous and unofficial names

cytochrome P450, subfamily IVF, polypeptide 11 | cytochrome P450, family 4, subfamily F, polypeptide 11

Genes

CYP4F11 (Hs)

Ensembl ID

ENSG00000171903 (Hs)

UniProtKB AC

Q9HBI6 (Hs)

EC number

1.14.14.1

1.14.14.78

CYP4F12 C Show summary »« Hide summary

Target Id

1348

Nomenclature

CYP4F12

Previous and unofficial names

cytochrome P450, subfamily IVF, polypeptide 12 | cytochrome P450, family 4, subfamily F, polypeptide 12

Genes

CYP4F12 (Hs)

Ensembl ID

ENSG00000186204 (Hs)

UniProtKB AC

Q9HCS2 (Hs)

EC number

1.14.14.1

Comment

AC004597.1 (ENSG00000225607) is described as being highly similar to CYP4F12

CYP4F22 C Show summary »« Hide summary

Target Id

1349

Nomenclature

CYP4F22

Previous and unofficial names

cytochrome P450, family 4, subfamily F, polypeptide 22

Genes

CYP4F22 (Hs)

Ensembl ID

ENSG00000171954 (Hs)

UniProtKB AC

Q6NT55 (Hs)

EC number

1.14.14.-

Comment

Converts arachidonic acid to 16-HETE and 18-HETE [7].

CYP4V2 C Show summary »« Hide summary

Target Id

1350

Nomenclature

CYP4V2

Previous and unofficial names

cytochrome P450 4V2 | cytochrome P450, family 4, subfamily V, polypeptide 2

Genes

CYP4V2 (Hs)

Ensembl ID

ENSG00000145476 (Hs)

UniProtKB AC

Q6ZWL3 (Hs)

EC number

1.14.14.79

Comment

Converts myristic acid to 14-hydroxymyristic acid [6].

CYP4X1 C Show summary »« Hide summary

Target Id

1351

Nomenclature

CYP4X1

Previous and unofficial names

cytochrome P450 4X1 | cytochrome P450, family 4, subfamily x, polypeptide 1 | cytochrome P450, family 4, subfamily X, polypeptide 1 | cytochrome P450

Genes

CYP4X1 (Hs), Cyp4x1 (Mm), Cyp4x1 (Rn)

Ensembl ID

ENSG00000186377 (Hs), ENSMUSG00000047155 (Mm), ENSRNOG00000043513 (Rn)

UniProtKB AC

Q8N118 (Hs), Q6A152 (Mm), Q8K4D6 (Rn)

EC number

1.14.14.1

Comment

Converts anandamide to 14,15-epoxyeicosatrienoic ethanolamide [10].

CYP4Z1 C Show summary »« Hide summary

Target Id

1352

Nomenclature

CYP4Z1

Previous and unofficial names

CYP4A20 | cytochrome P450, family 4, subfamily Z, polypeptide 1

Genes

CYP4Z1 (Hs)

Ensembl ID

ENSG00000186160 (Hs)

UniProtKB AC

Q86W10 (Hs)

EC number

1.14.14.1

Comment

Converts lauric acid to 12-hydroxylauric acid.

References

Show »« Hide

1. Bylund J, Hidestrand M, Ingelman-Sundberg M, Oliw EH. (2000) Identification of CYP4F8 in human seminal vesicles as a prominent 19-hydroxylase of prostaglandin endoperoxides. J. Biol. Chem., 275 (29): 21844-9. [PMID:10791960]

2. Fer M, Corcos L, Dréano Y, Plée-Gautier E, Salaün JP, Berthou F, Amet Y. (2008) Cytochromes P450 from family 4 are the main omega hydroxylating enzymes in humans: CYP4F3B is the prominent player in PUFA metabolism. J. Lipid Res., 49 (11): 2379-89. [PMID:18577768]

3. Gainer JV, Bellamine A, Dawson EP, Womble KE, Grant SW, Wang Y, Cupples LA, Guo CY, Demissie S, O'Donnell CJ et al.. (2005) Functional variant of CYP4A11 20-hydroxyeicosatetraenoic acid synthase is associated with essential hypertension. Circulation, 111 (1): 63-9. [PMID:15611369]

4. Harmon SD, Fang X, Kaduce TL, Hu S, Raj Gopal V, Falck JR, Spector AA. (2006) Oxygenation of omega-3 fatty acids by human cytochrome P450 4F3B: effect on 20-hydroxyeicosatetraenoic acid production. Prostaglandins Leukot. Essent. Fatty Acids, 75 (3): 169-77. [PMID:16820285]

5. Mizukami Y, Sumimoto H, Isobe R, Minakami S. (1993) Omega-hydroxylation of lipoxin B4 by human neutrophil microsomes: identification of omega-hydroxy metabolite of lipoxin B4 and catalysis by leukotriene B4 omega-hydroxylase (cytochrome P-450LTB omega). Biochim. Biophys. Acta, 1168 (1): 87-93. [PMID:8389204]

6. Nakano M, Kelly EJ, Rettie AE. (2009) Expression and characterization of CYP4V2 as a fatty acid omega-hydroxylase. Drug Metab. Dispos., 37 (11): 2119-22. [PMID:19661213]

7. Nilsson T, Ivanov IV, Oliw EH. (2010) LC-MS/MS analysis of epoxyalcohols and epoxides of arachidonic acid and their oxygenation by recombinant CYP4F8 and CYP4F22. Arch. Biochem. Biophys., 494 (1): 64-71. [PMID:19919823]

8. Shak S, Reich NO, Goldstein IM, Ortiz de Montellano PR. (1985) Leukotriene B4 omega-hydroxylase in human polymorphonuclear leukocytes. Suicidal inactivation by acetylenic fatty acids. J. Biol. Chem., 260 (24): 13023-8. [PMID:2997155]

9. Sontag TJ, Parker RS. (2002) Cytochrome P450 omega-hydroxylase pathway of tocopherol catabolism. Novel mechanism of regulation of vitamin E status. J. Biol. Chem., 277 (28): 25290-6. [PMID:11997390]

10. Stark K, Dostalek M, Guengerich FP. (2008) Expression and purification of orphan cytochrome P450 4X1 and oxidation of anandamide. FEBS J., 275 (14): 3706-17. [PMID:18549450]

How to cite this family page

Database page citation (select format):

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Mathie A, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Davies JA; CGTP Collaborators. (2019) The Concise Guide to PHARMACOLOGY 2019/20: Enzymes. Br J Pharmacol. 176 Issue S1: S297-S396.