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CYP4 family C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).


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CYP4 family enzymes catalyse the ω-oxidation of endogenous fatty acids and eicosanoids [4]. They have been proposed as molecular targets for the treatment of fatty acid-linked orphan diseases.


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CYP4A11 C Show summary »

CYP4A22 C Show summary »

CYP4B1 C Show summary »

CYP4F2 C Show summary »

Target Id 1344
Nomenclature CYP4F2
Previous and unofficial names Leukotriene B4 20-monooxygenase 1 | leukotriene B4 ω-hydroxylase 1 | cytochrome P450, family 4, subfamily F, polypeptide 2
Genes CYP4F2 (Hs)
Ensembl ID ENSG00000186115 (Hs)
UniProtKB AC P78329 (Hs)
EC number
17-octadecynoic acid pKi 5.9 [17]
sesamin pIC50 6.4 [22]
Comment Responsible for ω-hydroxylation of LTB4, LXB4 [11], and tocopherols, including vitamin E [19]. Associated with the warfarin response [24].

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CYP4F22 C Show summary »

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CYP4X1 C Show summary »

CYP4Z1 C Show summary »


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How to cite this family page

Database page citation (select format):

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Mathie AA, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Davies JA et al. (2023) The Concise Guide to PHARMACOLOGY 2023/24: Enzymes. Br J Pharmacol. 180 Suppl 2:S289-373.