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CYP4 family C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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CYP4 family enzymes catalyse the ω-oxidation of endogenous fatty acids and eicosanoids [4]. They have been proposed as molecular targets for the treatment of fatty acid-linked orphan diseases.

Enzymes

1349
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CYP4A11 C Show summary »

CYP4A22 C Show summary »

CYP4B1 C Show summary »

CYP4F2 C Show summary »

CYP4F3 C Show summary »

CYP4F8 C Show summary »

CYP4F11 C Show summary »

CYP4F12 C Show summary »

CYP4F22 C Show summary »


Target Id 1349
Nomenclature CYP4F22
Previous and unofficial names cytochrome P450, family 4, subfamily F, polypeptide 22
Genes CYP4F22 (Hs)
Ensembl ID ENSG00000171954 (Hs)
UniProtKB AC Q6NT55 (Hs)
EC number
1.14.14.-
Comment Converts arachidonic acid to 16-HETE and 18-HETE [13]. Involved in production of acylceramide and skin barrier integrity [15]. Variants may influence ichthyosis [5-6,14].

CYP4V2 C Show summary »

CYP4X1 C Show summary »

CYP4Z1 C Show summary »

References

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How to cite this family page

Database page citation (select format):

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Mathie A, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Davies JA; CGTP Collaborators. (2019) The Concise Guide to PHARMACOLOGY 2019/20: Enzymes. Br J Pharmacol. 176 Issue S1: S297-S396.