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CYP5, CYP7 and CYP8 families C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).


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Members of this enzyme family catalyse reactions in the pathways that synthesise or catabolise important lipid mediators, steroids and cholesterol.


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Thromboxane-A synthase (CYP5A1) C Show summary » More detailed page go icon to follow link

Cholesterol 7 alpha-hydroxylase (CYP7A1) C Show summary »

Target Id 1354
Nomenclature CYP7A1
Common abbreviation Cholesterol 7 alpha-hydroxylase
Previous and unofficial names cholesterol 7 alpha-monooxygenase | CHAP | cytochrome P450 (cholesterol hydroxylase 7 alpha) | cholesterol 7 alpha hydroxylase | cytochrome P450, family 7, subfamily a, polypeptide 1 | cytochrome P450, family 7, subfamily A, polypeptide 1 | cytochrome P450
Genes CYP7A1 (Hs), Cyp7a1 (Mm), Cyp7a1 (Rn)
Ensembl ID ENSG00000167910 (Hs), ENSMUSG00000028240 (Mm), ENSRNOG00000009488 (Rn)
UniProtKB AC P22680 (Hs), Q64505 (Mm), P18125 (Rn)
EC number
(2S,4S)-ketoconazole pIC50 9.7 [12]
Comment Converts cholesterol to 7α-hydroxycholesterol [9].

CYP7B1 C Show summary »

Prostacyclin synthase (CYP8A1) C Show summary »

CYP8B1 C Show summary »


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How to cite this family page

Database page citation (select format):

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Mathie AA, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Davies JA et al. (2023) The Concise Guide to PHARMACOLOGY 2023/24: Enzymes. Br J Pharmacol. 180 Suppl 2:S289-373.