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CYP5, CYP7 and CYP8 families C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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Members of this enzyme family catalyse reactions in the pathways that synthesise or catabolise important lipid mediators, steroids and cholesterol.

Enzymes

1355
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Thromboxane-A synthase (CYP5A1) C Show summary » More detailed page go icon to follow link

Cholesterol 7 alpha-hydroxylase (CYP7A1) C Show summary »

CYP7B1 C Show summary »


Target Id 1355
Nomenclature CYP7B1
Previous and unofficial names 25-hydroxycholesterol 7-α-hydroxylase | cytochrome P450 7B1 | cytochrome P450, subfamily 7B, polypeptide 1 | oxysterol 7-alpha-hydroxylase | cytochrome P450, family 7, subfamily B, polypeptide 1 | cytochrome P450, family 7, subfamily b, polypeptide 1 | cytochrome P450
Genes CYP7B1 (Hs), Cyp7b1 (Mm), Cyp7b1 (Rn)
Ensembl ID ENSG00000172817 (Hs), ENSMUSG00000039519 (Mm), ENSRNOG00000009730 (Rn)
UniProtKB AC O75881 (Hs), Q60991 (Mm), Q63688 (Rn)
EC number
1.14.14.29
Comment Converts dehydroepiandrosterone to 7α-DHEA [11].

Prostacyclin synthase (CYP8A1) C Show summary »

CYP8B1 C Show summary »

References

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How to cite this family page

Database page citation (select format):

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Mathie A, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Davies JA; CGTP Collaborators. (2019) The Concise Guide to PHARMACOLOGY 2019/20: Enzymes. Br J Pharmacol. 176 Issue S1: S297-S396.