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CYP5, CYP7 and CYP8 families C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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Members of this enzyme family catalyse reactions in the pathways that synthesise or catabolise important lipid mediators, steroids and cholesterol.

Enzymes

1357
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Thromboxane-A synthase (CYP5A1) C Show summary » More detailed page go icon to follow link

Cholesterol 7 alpha-hydroxylase (CYP7A1) C Show summary »

CYP7B1 C Show summary »

Prostacyclin synthase (CYP8A1) C Show summary »

CYP8B1 C Show summary »


Target Id 1357
Nomenclature CYP8B1
Previous and unofficial names sterol 12-α-hydroxylase | cytochrome P450 8b1 sterol 12 alpha-hydrolase | cytochrome P450, family 8, subfamily b, polypeptide 1 | 7-α-hydroxy-4-cholesten-3-one 12-α-hydroxylase | cytochrome P450 | cytochrome P450, family 8, subfamily B, polypeptide 1
Genes CYP8B1 (Hs), Cyp8b1 (Mm), Cyp8b1 (Rn)
Ensembl ID ENSG00000180432 (Hs), ENSMUSG00000050445 (Mm), ENSRNOG00000019481 (Rn)
UniProtKB AC Q9UNU6 (Hs), O88962 (Mm)
EC number
1.14.14.139
1.14.18.8
Comment Converts 7α-hydroxycholest-4-en-3-one to 7-alpha,12α-dihydroxycholest-4-en-3-one (in rabbit) [8] in the biosynthesis of bile acids.

References

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How to cite this family page

Database page citation (select format):

Concise Guide to PHARMACOLOGY citation:

Alexander SP, Fabbro D, Kelly E, Mathie A, Peters JA, Veale EL et al. (2021) THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: Enzymes. Br J Pharmacol. 178 Suppl 1:S313-S411.