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CYP11, CYP17, CYP19, CYP20 and CYP21 families C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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The reactions catalysed by this family of cytochrome P450 monooxygenases are required for steroid biosynthesis.

Enzymes

1364
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Cholesterol side-chain cleavage enzyme (CYP11A1) C Show summary » More detailed page go icon to follow link

Steroid 11β-hydroxylase (CYP11B1) C Show summary » More detailed page go icon to follow link

Aldosterone synthase (CYP11B2) C Show summary » More detailed page go icon to follow link

CYP17A1 C Show summary » More detailed page go icon to follow link

Aromatase (CYP19A1) C Show summary » More detailed page go icon to follow link

CYP20A1 C Show summary »

Steroid 21-hydroxylase (CYP21A2) C Show summary »


Target Id 1364
Nomenclature CYP21A2
Common abbreviation Steroid 21-hydroxylase
Previous and unofficial names Steroid 21-monooxygenase | Steroid 21-hydroxylase | cytochrome P450, family 21, subfamily A, polypeptide 2 | cytochrome P450, family 21, subfamily a, polypeptide 2 pseudogene | cytochrome P450
Genes CYP21A2 (Hs), Cyp21a2-ps (Mm)
Ensembl ID ENSG00000198457 (Hs), ENSMUSG00000092471 (Mm)
UniProtKB AC P08686 (Hs)
EC number
1.14.14.16
Inhibitors
(2S,4S)-ketoconazole pIC50 5.4 [12] - Rat
Comment Converts progesterone and 17α-hydroxyprogesterone to deoxycortisone and 11-deoxycortisol, respectively

References

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How to cite this family page

Database page citation (select format):

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Mathie A, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Davies JA; CGTP Collaborators. (2019) The Concise Guide to PHARMACOLOGY 2019/20: Enzymes. Br J Pharmacol. 176 Issue S1: S297-S396.