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CYP39, CYP46 and CYP51 families C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).


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Enzymes in this family are involved in cholesterol turnover and the biosynthesis of the crucial steroid precursor, lanosterol.


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CYP39A1 C Show summary »

Target Id 1372
Nomenclature CYP39A1
Previous and unofficial names 24-hydroxycholesterol 7-alpha-hydroxylase | oxysterol 7-alpha-hydroxylase | cytochrome P450, family 39, subfamily A, polypeptide 1 | cytochrome P450
Genes CYP39A1 (Hs), Cyp39a1 (Mm), Cyp39a1 (Rn)
Ensembl ID ENSG00000146233 (Hs), ENSMUSG00000023963 (Mm), ENSRNOG00000010519 (Rn)
UniProtKB AC Q9NYL5 (Hs), Q9JKJ9 (Mm)
EC number
Comment Converts 24-hydroxycholesterol to 7α,24-dihydroxycholesterol [2].

Cholesterol 24-hydroxylase (CYP46A1) C Show summary »

Lanosterol 14-α-demethylase (CYP51A1) C Show summary »


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How to cite this family page

Database page citation (select format):

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Mathie AA, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Davies JA et al. (2023) The Concise Guide to PHARMACOLOGY 2023/24: Enzymes. Br J Pharmacol. 180 Suppl 2:S289-373.