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CYP39, CYP46 and CYP51 families C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).


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Enzymes in this family are involved in cholesterol turnover and the biosynthesis of the crucial steroid precursor, lanosterol.


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CYP39A1 C Show summary »

Cholesterol 24-hydroxylase (CYP46A1) C Show summary »

Target Id 1373
Nomenclature CYP46A1
Common abbreviation Cholesterol 24-hydroxylase
Previous and unofficial names cytochrome P450, family 46, subfamily A, polypeptide 1 | cytochrome P450
Genes CYP46A1 (Hs), Cyp46a1 (Mm), Cyp46a1 (Rn)
Ensembl ID ENSG00000036530 (Hs), ENSMUSG00000021259 (Mm), ENSRNOG00000007147 (Rn)
UniProtKB AC Q9Y6A2 (Hs), Q9WVK8 (Mm)
EC number
soticlestat pIC50 8.4 [3]
Comment Converts cholesterol to 24(S)-hydroxycholesterol.

Lanosterol 14-α-demethylase (CYP51A1) C Show summary »


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How to cite this family page

Database page citation (select format):

Concise Guide to PHARMACOLOGY citation:

Alexander SP, Fabbro D, Kelly E, Mathie A, Peters JA, Veale EL et al. (2021) THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: Enzymes. Br J Pharmacol. 178 Suppl 1:S313-S411.