Top ▲

CYP39, CYP46 and CYP51 families C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).


Click here for help

« Hide

Enzymes in this family are involved in cholesterol turnover and the biosynthesis of the crucial steroid precursor, lanosterol.


Click here for help

CYP39A1 C Show summary »

Cholesterol 24-hydroxylase (CYP46A1) C Show summary »

Lanosterol 14-α-demethylase (CYP51A1) C Show summary »

Target Id 1374
Nomenclature CYP51A1
Common abbreviation Lanosterol 14-α-demethylase
Previous and unofficial names lanosterol 14-alpha demethylase | sterol 14-alpha demethylase | Cytochrom P450 Lanosterol 14 alpha-demethylase | cytochrome P450, family 51, subfamily A, polypeptide 1 | cytochrome P450
Genes CYP51A1 (Hs), Cyp51 (Mm), Cyp51 (Rn)
Ensembl ID ENSG00000001630 (Hs), ENSMUSG00000001467 (Mm), ENSRNOG00000007234 (Rn)
UniProtKB AC Q16850 (Hs), Q8K0C4 (Mm), Q64654 (Rn)
EC number
azalanstat pKi 9.1 [4]
compound 10 [PMID: 31663733] (Irreversible inhibition) pIC50 >6.0 [1]
Comment Converts lanosterol to 4,4-dimethylcholesta-8.14.24-trienol. Proteins within the cholesterol pathway are being investigated as potential oncology targets. Small molecule inhibitors of human CYP51A1 have been reported to exhibit anti-proliferative activity in various cancer cells [1].


Click here for help

Show »

How to cite this family page

Database page citation (select format):

Concise Guide to PHARMACOLOGY citation:

Alexander SP, Fabbro D, Kelly E, Mathie A, Peters JA, Veale EL et al. (2021) THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: Enzymes. Br J Pharmacol. 178 Suppl 1:S313-S411.