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Haem oxygenase C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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Haem oxygenase (heme,hydrogen-donor:oxygen oxidoreductase (α-methene-oxidizing, hydroxylating)), E.C. 1.14.99.3, converts heme into biliverdin and carbon monoxide, utilizing NADPH as cofactor.

Enzymes

1442
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HO1 (Haem oxygenase 1) C Show summary » More detailed page go icon to follow link

HO2 (Haem oxygenase 2) C Show summary »


Target Id 1442
Nomenclature Haem oxygenase 2
Common abbreviation HO2
Previous and unofficial names heme oxygenase-2 non-reducing isoform | HO-2 | heme oxygenase (decycling) 2
Genes HMOX2 (Hs), Hmox2 (Mm), Hmox2 (Rn)
Ensembl ID ENSG00000103415 (Hs), ENSMUSG00000004070 (Mm), ENSRNOG00000003773 (Rn)
UniProtKB AC P30519 (Hs), O70252 (Mm), P23711 (Rn)
EC number
1.14.14.18
Protoheme + 3 [reduced NADPH--hemoprotein reductase] + 3 O(2) <=> biliverdin + Fe(2+) + CO + 3 [oxidized NADPH--hemoprotein reductase] + 3 H(2)O
Inhibitors
compound 1 [PMID: 16821802] pIC50 3.5 [3] - Rat

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References

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NC-IUPHAR subcommittee and family contributors

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How to cite this family page

Database page citation (select format):

Concise Guide to PHARMACOLOGY citation:

Alexander SP, Fabbro D, Kelly E, Mathie A, Peters JA, Veale EL et al. (2021) THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: Enzymes. Br J Pharmacol. 178 Suppl 1:S313-S411.