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Haem oxygenase C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).


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Haem oxygenase (heme,hydrogen-donor:oxygen oxidoreductase (α-methene-oxidizing, hydroxylating)), E.C., converts heme into biliverdin and carbon monoxide, utilizing NADPH as cofactor.


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HO1 (Haem oxygenase 1) C Show summary » More detailed page go icon to follow link

HO2 (Haem oxygenase 2) C Show summary »

Target Id 1442
Nomenclature Haem oxygenase 2
Common abbreviation HO2
Previous and unofficial names heme oxygenase-2 non-reducing isoform | HO-2 | heme oxygenase (decycling) 2
Genes HMOX2 (Hs), Hmox2 (Mm), Hmox2 (Rn)
Ensembl ID ENSG00000103415 (Hs), ENSMUSG00000004070 (Mm), ENSRNOG00000003773 (Rn)
UniProtKB AC P30519 (Hs), O70252 (Mm), P23711 (Rn)
EC number
Protoheme + 3 [reduced NADPH--hemoprotein reductase] + 3 O(2) <=> biliverdin + Fe(2+) + CO + 3 [oxidized NADPH--hemoprotein reductase] + 3 H(2)O
compound 1 [PMID: 16821802] pIC50 3.5 [3] - Rat


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Further reading

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NC-IUPHAR subcommittee and family contributors

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How to cite this family page

Database page citation (select format):

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Mathie AA, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Davies JA et al. (2023) The Concise Guide to PHARMACOLOGY 2023/24: Enzymes. Br J Pharmacol. 180 Suppl 2:S289-373.