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Inositol 1,4,5-trisphosphate 3-kinases C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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Inositol 1,4,5-trisphosphate 3-kinases (E.C. 2.7.1.127, ENSFM00250000001260) catalyse the generation of inositol 1,3,4,5-tetrakisphosphate (IP4) from IP3. IP3 kinase activity is enhanced in the presence of calcium/calmodulin (CALM2, CALM3, CALM1, P62158) [1].

Enzymes

1449
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IP3 kinase A Show summary »

IP3 kinase B Show summary » More detailed page go icon to follow link

IP3 kinase C Show summary »


Target Id 1449
Nomenclature IP3 kinase C
Previous and unofficial names inositol 1,4,5-trisphosphate 3-kinase C | insP 3-kinase C | IP3KC | inositol 1
Genes ITPKC (Hs), Itpkc (Mm), Itpkc (Rn)
Ensembl ID ENSG00000086544 (Hs), ENSMUSG00000003752 (Mm), ENSRNOG00000013945 (Rn)
UniProtKB AC Q96DU7 (Hs), Q7TS72 (Mm), Q80ZG2 (Rn)
EC number
2.7.1.127
Inhibitors
GNF362 pIC50 7.7 [2]

References

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How to cite this family page

Database page citation:

Inositol 1,4,5-trisphosphate 3-kinases. Accessed on 14/07/2024. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=280.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Mathie AA, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Davies JA et al. (2023) The Concise Guide to PHARMACOLOGY 2023/24: Enzymes. Br J Pharmacol. 180 Suppl 2:S289-373.