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GDNF receptor family C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).


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GDNF family receptors (provisional nomenclature) are extrinsic tyrosine kinase receptors. Ligand binding to the extracellular domain of the glycosylphosphatidylinositol-linked cell-surface receptors (tabulated below) activates a transmembrane tyrosine kinase enzyme, RET (see Receptor Tyrosine Kinases). The endogenous ligands are typically dimeric, linked through disulphide bridges: glial cell-derived neurotrophic factor GDNF (GDNF, P39905) (211 aa); neurturin (NRTN, Q99748) (197 aa); artemin (ARTN, Q5T4W7) (237 aa) and persephin (PSPN, O60542) (PSPN, 156 aa).


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GFRα1 (GDNF family receptor α1) C Show summary »

GFRα2 (GDNF family receptor α2) C Show summary »

GFRα3 (GDNF family receptor α3) C Show summary »

GFRα4 (GDNF family receptor α4) C Show summary »

Target Id 1746
Nomenclature GDNF family receptor α4
Common abbreviation GFRα4
Previous and unofficial names GDNF family receptor alpha 4 | glial cell line derived neurotrophic factor family receptor alpha 4 | Persephin receptor
Genes GFRA4 (Hs), Gfra4 (Mm), Gfra4 (Rn)
Ensembl ID ENSG00000125861 (Hs), ENSMUSG00000027316 (Mm), ENSRNOG00000021241 (Rn)
UniProtKB AC Q9GZZ7 (Hs), Q9JJT2 (Mm), Q9EPI2 (Rn)
Potency order persephin (PSPN, O60542)

GDNF family receptor alpha like Show summary »


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Further reading

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How to cite this family page

Database page citation:

GDNF receptor family. Accessed on 14/06/2024. IUPHAR/BPS Guide to PHARMACOLOGY,

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Mathie AA, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Davies JA et al. (2023) The Concise Guide to PHARMACOLOGY 2023/24: Catalytic receptors. Br J Pharmacol. 180 Suppl 2:S241-288.