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GDNF receptor family C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).


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GDNF family receptors (provisional nomenclature) are extrinsic tyrosine kinase receptors. Ligand binding to the extracellular domain of the glycosylphosphatidylinositol-linked cell-surface receptors (tabulated below) activates a transmembrane tyrosine kinase enzyme, RET (see Receptor Tyrosine Kinases). The endogenous ligands are typically dimeric, linked through disulphide bridges: glial cell-derived neurotrophic factor GDNF (GDNF, P39905) (211 aa); neurturin (NRTN, Q99748) (197 aa); artemin (ARTN, Q5T4W7) (237 aa) and persephin (PSPN, O60542) (PSPN, 156 aa).


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GFRα1 (GDNF family receptor α1) C Show summary »

GFRα2 (GDNF family receptor α2) C Show summary »

GFRα3 (GDNF family receptor α3) C Show summary »

GFRα4 (GDNF family receptor α4) C Show summary »

GDNF family receptor alpha like Show summary »

Target Id 2977
Nomenclature GDNF family receptor alpha like
Previous and unofficial names GRAL
Genes GFRAL (Hs), Gfral (Mm), Gfral (Rn)
Ensembl ID ENSG00000187871 (Hs), ENSMUSG00000059383 (Mm), ENSRNOG00000032063 (Rn)
UniProtKB AC Q6UXV0 (Hs), Q6SJE0 (Mm)
Endogenous agonists
growth differentiation factor 15 (GDF15) [1]
Comment GFRAL is proposed as the receptor for the peptide hormone GDF15 (MIC-1) [1,4,6].


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Further reading

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How to cite this family page

Database page citation:

GDNF receptor family. Accessed on 29/09/2021. IUPHAR/BPS Guide to PHARMACOLOGY,

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Mathie A, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Davies JA; CGTP Collaborators. (2019) The Concise Guide to PHARMACOLOGY 2019/20: Catalytic receptors. Br J Pharmacol. 176 Suppl 1: S247-S296.