Oxoglutarate receptor | G protein-coupled receptors | IUPHAR/BPS Guide to PHARMACOLOGY

Home
Targets
G protein-coupled receptors
Oxoglutarate receptor

Oxoglutarate receptor C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

Show »« Hide More detailed introduction go icon to follow link

Nomenclature as recommended by NC-IUPHAR [1].

Receptors

oxoglutarate receptor C Show summary »« Hide summary More detailed page go icon to follow link

Target Id

162

Nomenclature

oxoglutarate receptor

Previous and unofficial names

P2RY15 | GPR80 | GPR99 | P2Y15 | 2-oxoglutarate receptor 1 | Alpha-ketoglutarate receptor 1 | G protein-coupled receptor 99 | P2Y purinoceptor 15 | G protein-coupled receptor 80

Genes

OXGR1 (Hs), Oxgr1 (Mm), Oxgr1 (Rn)

Ensembl ID

ENSG00000165621 (Hs), ENSMUSG00000044819 (Mm), ENSRNOG00000037884 (Rn)

UniProtKB AC

Q96P68 (Hs), Q6IYF8 (Mm), Q6Y1R5 (Rn)

Principal transduction

G_q/G₁₁ family

Endogenous agonists

α-ketoglutaric acid [2-3]

References

Show »« Hide

1. Davenport AP, Alexander SP, Sharman JL, Pawson AJ, Benson HE, Monaghan AE, Liew WC, Mpamhanga CP, Bonner TI, Neubig RR et al.. (2013) International Union of Basic and Clinical Pharmacology. LXXXVIII. G protein-coupled receptor list: recommendations for new pairings with cognate ligands. Pharmacol Rev, 65 (3): 967-86. [PMID:23686350]

2. He W, Miao FJ, Lin DC, Schwandner RT, Wang Z, Gao J, Chen JL, Tian H, Ling L. (2004) Citric acid cycle intermediates as ligands for orphan G-protein-coupled receptors. Nature, 429 (6988): 188-93. [PMID:15141213]

3. Southern C, Cook JM, Neetoo-Isseljee Z, Taylor DL, Kettleborough CA, Merritt A, Bassoni DL, Raab WJ, Quinn E, Wehrman TS et al.. (2013) Screening β-Arrestin Recruitment for the Identification of Natural Ligands for Orphan G-Protein-Coupled Receptors. J Biomol Screen, 18 (5): 599-609. [PMID:23396314]

NC-IUPHAR subcommittee and family contributors

Show »« Hide

How to cite this family page

Database page citation (select format):

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Christopoulos A, Davenport AP, Kelly E, Mathie AA, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Davies JA et al. (2023) The Concise Guide to PHARMACOLOGY 2023/24: G protein-coupled receptors. Br J Pharmacol. 180 Suppl 2:S23-S144.