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QIK subfamily

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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The salt-inducible kinases (SIKs) control a novel molecular switch regulating macrophage polarization. Inhibition of SIKs is reported to promote a macrophage phenotype switch to a 'regulatory'-like phenotype [2-3], that favours resolution of inflammation. This action of SIKs provides a novel intervention point for pharmacological agents with potential as therapeutics for chronic inflammatory diseases.

Enzymes

SIK (salt inducible kinase 1) Show summary » More detailed page

QIK (salt inducible kinase 2) Show summary » More detailed page

QSK (SIK family kinase 3) Show summary » More detailed page

References

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How to cite this family page

Database page citation:

QIK subfamily. Accessed on 09/12/2019. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=483.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Mathie A, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Davies JA; CGTP Collaborators. (2019) The Concise Guide to PHARMACOLOGY 2019/20: Enzymes. Br J Pharmacol. 176 Issue S1: S297-S396.