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CDK8 subfamily

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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CDK8 and CDK19 act as subunits of mammalian mediator complexes, which are essential regulators of RNA polymerase II transcriptional machinery [1]. CDK8 is also an oncogene and hence a molecular target for the developmet of novel anti-cancer therapeutics [2-4].

Enzymes

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CDK8 (cyclin dependent kinase 8) Show summary » More detailed page go icon to follow link

CDK19 (cyclin dependent kinase 19) Show summary » More detailed page go icon to follow link

References

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How to cite this family page

Database page citation:

CDK8 subfamily. Accessed on 28/11/2021. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=497.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Mathie A, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Davies JA; CGTP Collaborators. (2019) The Concise Guide to PHARMACOLOGY 2019/20: Enzymes. Br J Pharmacol. 176 Issue S1: S297-S396.