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TAO subfamily
Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).
Overview
The human genome encodes three thousand and one amino acid (TAO) kinase genes. The enzymes regulate MAPK and Hippo signaling pathways and have pleiotropic functions, participating in a range of cellular processes including stress responses, cell proliferation, immune responses and neurodevelopment [1]. Whilst the N-terminal catalytic domains of the three TAOKs are conserved, divergent non-catalytic functions appear to be mediated by regulatory domains in the protein structures, Dysregulated activity has been associated with neurological disorders.
Enzymes
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TAO1 (TAO kinase 1)
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TAO2 (TAO kinase 2)
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TAO3 (TAO kinase 3)
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How to cite this family page
Database page citation:
TAO subfamily. Accessed on 05/07/2025. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=551.
Concise Guide to PHARMACOLOGY citation:
Alexander SPH, Fabbro D, Kelly E, Mathie AA, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Davies JA et al. (2023) The Concise Guide to PHARMACOLOGY 2023/24: Enzymes. Br J Pharmacol. 180 Suppl 2:S289-373.
