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Ack family C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).


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TNK2 (ACK1) is a tyrosine kinase that induces cell survival mechanisms. Substrates include receptor tyrosine kinases (EGFR, MERTK, AXL, HER2 and insulin receptor), AKT, FYN, the androgen receptor and the GTPase Cdc42Hs. TNK2 is associated with tumour cell survival, proliferation and hormone-resistance, and hence TNK2 is considered to be a novel cancer target, although no inhibitors have entered clinical trials.


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Tnk1 (tyrosine kinase non receptor 1) Show summary » More detailed page go icon to follow link

Ack (tyrosine kinase non receptor 2) C Show summary » More detailed page go icon to follow link


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How to cite this family page

Database page citation:

Ack family. Accessed on 21/07/2024. IUPHAR/BPS Guide to PHARMACOLOGY,

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Mathie AA, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Davies JA et al. (2023) The Concise Guide to PHARMACOLOGY 2023/24: Enzymes. Br J Pharmacol. 180 Suppl 2:S289-373.