Casein kinase 2 (CK2) family

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Enzymes

CK2 (Casein kinase 2) Show summary »« Hide summary More detailed page

Target Id

1548

Nomenclature

Casein kinase 2

Common abbreviation

CK2

EC number

2.7.11.1

Inhibitors

compound 5b [PMID: 24900464] pIC₅₀ 8.3 [2]

Selective inhibitors

DRB [5]

Comment

Casein kinase 2 is a heterotetrameric protein kinase, made up of 2 β subunits with two other subunits of α and/or α' composition.

CK2-A1 (casein kinase 2, alpha 1 polypeptide subunit) Show summary »« Hide summary More detailed page

CK2-A2 (casein kinase 2, alpha prime polypeptide subunit) Show summary »« Hide summary More detailed page

CK2-B (casein kinase 2, beta polypeptide subunit) Show summary »« Hide summary More detailed page

Target Id

1551

Nomenclature

casein kinase 2, beta polypeptide subunit

Common abbreviation

CK2-B

Previous and unofficial names

casein kinase II beta subunit | phosvitin | Protein G5a | casein kinase 2

Genes

CSNK2B (Hs), Csnk2b (Mm), Csnk2b (Rn)

Ensembl ID

ENSG00000204435 (Hs), ENSMUSG00000024387 (Mm), ENSRNOG00000000847 (Rn)

UniProtKB AC

P67870 (Hs), P67871 (Mm), P67874 (Rn)

EC number

2.7.11.1

References

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1. Dowling JE, Alimzhanov M, Bao L, Block MH, Chuaqui C, Cooke EL, Denz CR, Hird A, Huang S, Larsen NA et al.. (2013) Structure and Property Based Design of Pyrazolo[1,5-a]pyrimidine Inhibitors of CK2 Kinase with Activity in Vivo. ACS Med Chem Lett, 4 (8): 800-5. [PMID:24900749]

2. Dowling JE, Chuaqui C, Pontz TW, Lyne PD, Larsen NA, Block MH, Chen H, Su N, Wu A, Russell D et al.. (2012) Potent and Selective Inhibitors of CK2 Kinase Identified through Structure-Guided Hybridization. ACS Med Chem Lett, 3 (4): 278-83. [PMID:24900464]

3. Janeczko M, Orzeszko A, Kazimierczuk Z, Szyszka R, Baier A. (2012) CK2α and CK2α' subunits differ in their sensitivity to 4,5,6,7-tetrabromo- and 4,5,6,7-tetraiodo-1H-benzimidazole derivatives. Eur J Med Chem, 47 (1): 345-50. [PMID:22115617]

4. Pierre F, Chua PC, O'Brien SE, Siddiqui-Jain A, Bourbon P, Haddach M, Michaux J, Nagasawa J, Schwaebe MK, Stefan E et al.. (2011) Discovery and SAR of 5-(3-chlorophenylamino)benzo[c][2,6]naphthyridine-8-carboxylic acid (CX-4945), the first clinical stage inhibitor of protein kinase CK2 for the treatment of cancer. J. Med. Chem., 54 (2): 635-54. [PMID:21174434]

5. Zandomeni R, Zandomeni MC, Shugar D, Weinmann R. (1986) Casein kinase type II is involved in the inhibition by 5,6-dichloro-1-beta-D-ribofuranosylbenzimidazole of specific RNA polymerase II transcription. J. Biol. Chem., 261 (7): 3414-9. [PMID:3456346]

How to cite this family page

Database page citation:

Casein kinase 2 (CK2) family. Accessed on 25/04/2019. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=565.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Marrion NV, Peters JA, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Davies JA; CGTP Collaborators. (2017) The Concise Guide to PHARMACOLOGY 2017/18: Enzymes. Br J Pharmacol. 174 Suppl 1: S272-S359.