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Death-associated kinase (DAPK) family

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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Death-associated kinases (DAPKs) are tumour suppressor genes [1]. Family members share homologous catalytic domains and cell death-associated functions. DAPK activity is required for cell death induced by death receptor signalling, cytokines, matrix detachment, and oncogene-induced hyperproliferation. Loss of DAPK function is identified in many cancers.

Enzymes

DAPK1 (death associated protein kinase 1) Show summary » More detailed page

DAPK2 (death associated protein kinase 2) Show summary » More detailed page

DAPK3 (death associated protein kinase 3) Show summary » More detailed page

DRAK1 (serine/threonine kinase 17a) Show summary » More detailed page

DRAK2 (serine/threonine kinase 17b) Show summary » More detailed page

References

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How to cite this family page

Database page citation:

Death-associated kinase (DAPK) family. Accessed on 19/06/2019. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=572.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Marrion NV, Peters JA, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Davies JA; CGTP Collaborators. (2017) The Concise Guide to PHARMACOLOGY 2017/18: Enzymes. Br J Pharmacol. 174 Suppl 1: S272-S359.