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Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).
Death-associated kinases (DAPKs) are tumour suppressor genes [1]. Family members share homologous catalytic domains and cell death-associated functions. DAPK activity is required for cell death induced by death receptor signalling, cytokines, matrix detachment, and oncogene-induced hyperproliferation. Loss of DAPK function is identified in many cancers.
DAPK1 (death associated protein kinase 1)
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DAPK2 (death associated protein kinase 2)
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DAPK3 (death associated protein kinase 3)
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DRAK1 (serine/threonine kinase 17a)
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DRAK2 (serine/threonine kinase 17b)
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Database page citation:
Death-associated kinase (DAPK) family. Accessed on 19/05/2022. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=572.
Concise Guide to PHARMACOLOGY citation:
Alexander SPH, Fabbro D, Kelly E, Mathie A, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Davies JA; CGTP Collaborators. (2019) The Concise Guide to PHARMACOLOGY 2019/20: Enzymes. Br J Pharmacol. 176 Issue S1: S297-S396.