Death-associated kinase (DAPK) family
Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).
Overview
Death-associated kinases (DAPKs) are tumour suppressor genes [1]. Family members share homologous catalytic domains and cell death-associated functions. DAPK activity is required for cell death induced by death receptor signalling, cytokines, matrix detachment, and oncogene-induced hyperproliferation. Loss of DAPK function is identified in many cancers.
Enzymes
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DAPK1 (death associated protein kinase 1)
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DAPK2 (death associated protein kinase 2)
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DAPK3 (death associated protein kinase 3)
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DRAK1 (serine/threonine kinase 17a)
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DRAK2 (serine/threonine kinase 17b)
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How to cite this family page
Database page citation:
Death-associated kinase (DAPK) family. Accessed on 19/08/2019. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=572.
Concise Guide to PHARMACOLOGY citation:
Alexander SPH, Fabbro D, Kelly E, Marrion NV, Peters JA, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Davies JA; CGTP Collaborators. (2017) The Concise Guide to PHARMACOLOGY 2017/18: Enzymes. Br J Pharmacol. 174 Suppl 1: S272-S359.
