Death-associated kinase (DAPK) family

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Death-associated kinase (DAPK) family

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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Death-associated kinases (DAPKs) are tumour suppressor genes [1]. Family members share homologous catalytic domains and cell death-associated functions. DAPK activity is required for cell death induced by death receptor signalling, cytokines, matrix detachment, and oncogene-induced hyperproliferation. Loss of DAPK function is identified in many cancers.

Enzymes

DAPK1 (death associated protein kinase 1) Show summary »« Hide summary More detailed page go icon to follow link

Target Id

2002

Nomenclature

death associated protein kinase 1

Common abbreviation

DAPK1

Previous and unofficial names

DAP kinase 1 | DAP-Kinase | death-associated protein kinase 1

Genes

DAPK1 (Hs), Dapk1 (Mm), Dapk1 (Rn)

Ensembl ID

ENSG00000196730 (Hs), ENSMUSG00000021559 (Mm), ENSRNOG00000018198 (Rn)

UniProtKB AC

P53355 (Hs), Q80YE7 (Mm)

EC number

2.7.11.1

DAPK2 (death associated protein kinase 2) Show summary »« Hide summary More detailed page go icon to follow link

DAPK3 (death associated protein kinase 3) Show summary »« Hide summary More detailed page go icon to follow link

DRAK1 (serine/threonine kinase 17a) Show summary »« Hide summary More detailed page go icon to follow link

Target Id

2214

Nomenclature

serine/threonine kinase 17a

Common abbreviation

DRAK1

Previous and unofficial names

death-associated protein kinase-related 1

Genes

STK17A (Hs)

Ensembl ID

ENSG00000164543 (Hs)

UniProtKB AC

Q9UEE5 (Hs)

EC number

2.7.11.1

DRAK2 (serine/threonine kinase 17b) Show summary »« Hide summary More detailed page go icon to follow link

Target Id

2215

Nomenclature

serine/threonine kinase 17b

Common abbreviation

DRAK2

Previous and unofficial names

DAP kinase-related apoptosis-inducing protein kinase 2 | death-associated protein kinase-related 2

Genes

STK17B (Hs), Stk17b (Mm), Stk17b (Rn)

Ensembl ID

ENSG00000081320 (Hs), ENSMUSG00000026094 (Mm), ENSRNOG00000012502 (Rn)

UniProtKB AC

O94768 (Hs), Q8BG48 (Mm), Q91XS8 (Rn)

EC number

2.7.11.1

References

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How to cite this family page

Database page citation:

Death-associated kinase (DAPK) family. Accessed on 16/05/2021. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=572.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Mathie A, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Davies JA; CGTP Collaborators. (2019) The Concise Guide to PHARMACOLOGY 2019/20: Enzymes. Br J Pharmacol. 176 Issue S1: S297-S396.