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Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).
Death-associated kinases (DAPKs) are tumour suppressor genes [1]. Family members share homologous catalytic domains and cell death-associated functions. DAPK activity is required for cell death induced by death receptor signalling, cytokines, matrix detachment, and oncogene-induced hyperproliferation. Loss of DAPK function is identified in many cancers.
DAPK1 (death associated protein kinase 1)
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DAPK2 (death associated protein kinase 2)
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DAPK3 (death associated protein kinase 3)
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DRAK1 (serine/threonine kinase 17a)
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DRAK2 (serine/threonine kinase 17b)
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Database page citation:
Death-associated kinase (DAPK) family. Accessed on 01/07/2025. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=572.
Concise Guide to PHARMACOLOGY citation:
Alexander SPH, Fabbro D, Kelly E, Mathie AA, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Davies JA et al. (2023) The Concise Guide to PHARMACOLOGY 2023/24: Enzymes. Br J Pharmacol. 180 Suppl 2:S289-373.