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Polo-like kinase (PLK) family C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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The Polo-like kinases (PLK) are Ser/Thr kinases of the cell cycle that are involved in regulating mitotic entry, mitotic exit, spindle formation, cytokinesis, and meiosis [1,6]. PLK inhibitors are predicted to offer anti-proliferative potential for application in oncology [7,10].

Enzymes

PLK1 (polo like kinase 1) Show summary » More detailed page

PLK2 (polo like kinase 2) Show summary » More detailed page

PLK3 (polo like kinase 3) Show summary » More detailed page

PLK4 (polo like kinase 4) C Show summary » More detailed page

References

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How to cite this family page

Database page citation:

Polo-like kinase (PLK) family. Accessed on 23/10/2020. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=602.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Mathie A, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Davies JA; CGTP Collaborators. (2019) The Concise Guide to PHARMACOLOGY 2019/20: Enzymes. Br J Pharmacol. 176 Issue S1: S297-S396.