1-phosphatidylinositol 4-kinase family

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Lipid modifying kinases
1-phosphatidylinositol 4-kinase family

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Enzymes

PI4KIIIα/PIK4CA (phosphatidylinositol 4-kinase alpha) C Show summary »« Hide summary More detailed page go icon to follow link

Target Id

2148

Nomenclature

phosphatidylinositol 4-kinase alpha

Common abbreviation

PI4KIIIα/PIK4CA

Previous and unofficial names

phosphatidylinositol 4-kinase, catalytic, alpha | leuserpin 2 | PI4K-alpha | PtdIns-4-kinase alpha

Genes

PI4KA (Hs), Pi4ka (Mm), Pi4ka (Rn)

Ensembl ID

ENSG00000241973 (Hs), ENSMUSG00000041720 (Mm), ENSRNOG00000060045 (Rn)

UniProtKB AC

P42356 (Hs)

EC number

2.7.1.67

Sub/family-selective inhibitors

wortmannin pIC₅₀ 6.7 – 6.8 [2,5]

PI4KIIIβ/PIK4CB (phosphatidylinositol 4-kinase beta) C Show summary »« Hide summary More detailed page go icon to follow link

Target Id

2149

Nomenclature

phosphatidylinositol 4-kinase beta

Common abbreviation

PI4KIIIβ/PIK4CB

Previous and unofficial names

phosphatidylinositol 4-kinase, catalytic, beta | phosphatidylinositol 4-kinase, catalytic, beta polypeptide | PI4Kbeta | ptdIns 4-kinase beta

Genes

PI4KB (Hs), Pi4kb (Mm), Pi4kb (Rn)

Ensembl ID

ENSG00000143393 (Hs), ENSMUSG00000038861 (Mm), ENSRNOG00000021024 (Rn)

UniProtKB AC

Q9UBF8 (Hs), Q8BKC8 (Mm), O08561 (Rn)

EC number

2.7.1.67

Endogenous activation

PKD-mediated phosphorylation [3]

Sub/family-selective inhibitors

wortmannin pIC₅₀ 6.7 – 6.8 [2,5]

Selective inhibitors

PIK-93 pIC₅₀ 7.7 [1,4]

References

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1. Balla A, Kim YJ, Varnai P, Szentpetery Z, Knight Z, Shokat KM, Balla T. (2008) Maintenance of hormone-sensitive phosphoinositide pools in the plasma membrane requires phosphatidylinositol 4-kinase IIIalpha. Mol Biol Cell, 19 (2): 711-21. [PMID:18077555]

2. Gehrmann T, Gülkan H, Suer S, Herberg FW, Balla A, Vereb G, Mayr GW, Heilmeyer Jr LM. (1999) Functional expression and characterisation of a new human phosphatidylinositol 4-kinase PI4K230. Biochim Biophys Acta, 1437 (3): 341-56. [PMID:10101268]

3. Hausser A, Storz P, Märtens S, Link G, Toker A, Pfizenmaier K. (2005) Protein kinase D regulates vesicular transport by phosphorylating and activating phosphatidylinositol-4 kinase IIIbeta at the Golgi complex. Nat Cell Biol, 7 (9): 880-6. [PMID:16100512]

4. Knight ZA, Gonzalez B, Feldman ME, Zunder ER, Goldenberg DD, Williams O, Loewith R, Stokoe D, Balla A, Toth B et al.. (2006) A pharmacological map of the PI3-K family defines a role for p110alpha in insulin signaling. Cell, 125 (4): 733-47. [PMID:16647110]

5. Meyers R, Cantley LC. (1997) Cloning and characterization of a wortmannin-sensitive human phosphatidylinositol 4-kinase. J Biol Chem, 272 (7): 4384-90. [PMID:9020160]

How to cite this family page

Database page citation:

1-phosphatidylinositol 4-kinase family. Accessed on 26/09/2023. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=638.

Concise Guide to PHARMACOLOGY citation:

Alexander SP, Fabbro D, Kelly E, Mathie A, Peters JA, Veale EL et al. (2021) THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: Enzymes. Br J Pharmacol. 178 Suppl 1:S313-S411.