Top ▲

Type XVIII RTKs: LMR family C

Formerly known as: Lmr family

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

Click here for help

« Hide

The LMR kinases are unusual amongst the RTKs in possessing a short extracellular domain and extended intracellular domain (hence the ‘Lemur’ name reflecting the long tail). A precise function for these receptors has yet to be defined, although LMR1 was identified as a potential marker of apoptosis [1], giving rise to the name AATYK (Apoptosis-associated tyrosine kinase); while over-expression induces differentiation in neuroblastoma cells [2].

Receptors

Click here for help

Lmr1 (apoptosis associated tyrosine kinase) C Show summary » More detailed page go icon to follow link

Lmr2 (lemur tyrosine kinase 2) C Show summary » More detailed page go icon to follow link

Lmr3 (lemur tyrosine kinase 3) C Show summary » More detailed page go icon to follow link

Comments

Click here for help

Show »

References

Click here for help

Show »

How to cite this family page

Database page citation:

Type XVIII RTKs: LMR family. Accessed on 05/08/2021. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=658.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Mathie A, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Davies JA; CGTP Collaborators. (2019) The Concise Guide to PHARMACOLOGY 2019/20: Catalytic receptors. Br J Pharmacol. 176 Suppl 1: S247-S296.