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Acid ceramidase C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).


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The six human ceramidases may be divided on the basis of pH optimae into acid, neutral and alkaline ceramidases, which also differ in their subcellular location.


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N-acylsphingosine amidohydrolase 1 C Show summary »

Target Id 2491
Nomenclature N-acylsphingosine amidohydrolase 1
Previous and unofficial names AC | ACDase | Acylsphingosine deacylase | N-acylsphingosine amidohydrolase (acid ceramidase) 1
Genes ASAH1 (Hs), Asah1 (Mm), Asah1 (Rn)
Ensembl ID ENSG00000104763 (Hs), ENSMUSG00000031591 (Mm), ENSRNOG00000010034 (Rn)
UniProtKB AC Q13510 (Hs), Q9WV54 (Mm), Q6P7S1 (Rn)
EC number ceramide -> sphingosine + a fatty acid
Comment This lysosomal enzyme is proteolysed to form the mature protein made up of two chains from the same gene product [1].


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How to cite this family page

Database page citation (select format):

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Mathie AA, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Davies JA et al. (2023) The Concise Guide to PHARMACOLOGY 2023/24: Enzymes. Br J Pharmacol. 180 Suppl 2:S289-373.