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Neutral ceramidases C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).


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The six human ceramidases may be divided on the basis of pH optimae into acid, neutral and alkaline ceramidases, which also differ in their subcellular location.


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N-acylsphingosine amidohydrolase 2 C Show summary »

Target Id 2492
Nomenclature N-acylsphingosine amidohydrolase 2
Previous and unofficial names Acylsphingosine deacylase 2 | BCDase | LCDase | NCDase | Neutral ceramidase | neutral/alkaline ceramidase | N-acylsphingosine amidohydrolase (non-lysosomal ceramidase) 2
Genes ASAH2 (Hs), Asah2 (Mm), Asah2 (Rn)
Ensembl ID ENSG00000188611 (Hs), ENSMUSG00000024887 (Mm), ENSRNOG00000012196 (Rn)
UniProtKB AC Q9NR71 (Hs), Q9JHE3 (Mm), Q91XT9 (Rn)
EC number ceramide -> sphingosine + a fatty acid
Comment The enzyme is associated with the plasma membrane [1].

N-acylsphingosine amidohydrolase 2B C Show summary »


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How to cite this family page

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Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Mathie A, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Davies JA; CGTP Collaborators. (2019) The Concise Guide to PHARMACOLOGY 2019/20: Enzymes. Br J Pharmacol. 176 Issue S1: S297-S396.