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Sphingomyelin phosphodiesterase C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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Also known as sphingomyelinase.

Enzymes

2514
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sphingomyelin phosphodiesterase 1 C Show summary »


Target Id 2514
Nomenclature sphingomyelin phosphodiesterase 1
Previous and unofficial names Acid sphingomyelinase | ASM | aSMase | Zn-SMase | sphingomyelin phosphodiesterase 1, acid lysosomal
Genes SMPD1 (Hs), Smpd1 (Mm), Smpd1 (Rn)
Ensembl ID ENSG00000166311 (Hs), ENSMUSG00000037049 (Mm), ENSRNOG00000017977 (Rn)
UniProtKB AC P17405 (Hs), Q04519 (Mm), Q5XIA6 (Rn)
EC number
3.1.4.12 sphingomyelin -> ceramide + phosphocholine
Inhibitors
compound 21b [PMID: 31944697] pIC50 6.5 [2]
WJYK50 pIC50 6.3 [1], 6.1 [2]

sphingomyelin phosphodiesterase 2 C Show summary »

sphingomyelin phosphodiesterase 3 C Show summary »

sphingomyelin phosphodiesterase 4 C Show summary »

sphingomyelin phosphodiesterase acid-like 3A C Show summary »

sphingomyelin phosphodiesterase acid-like 3B C Show summary »

References

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Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Mathie A, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Davies JA; CGTP Collaborators. (2019) The Concise Guide to PHARMACOLOGY 2019/20: Enzymes. Br J Pharmacol. 176 Issue S1: S297-S396.