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Sphingomyelin phosphodiesterase C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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Also known as sphingomyelinase.

Enzymes

2515
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sphingomyelin phosphodiesterase 1 C Show summary »

sphingomyelin phosphodiesterase 2 C Show summary »


Target Id 2515
Nomenclature sphingomyelin phosphodiesterase 2
Previous and unofficial names ISC1 | nSMase | N-Smase | sphingomyelin phosphodiesterase 2, neutral membrane (neutral sphingomyelinase) | sphingomyelin phosphodiesterase 2, neutral membrane | sphingomyelin phosphodiesterase 2, neutral
Genes SMPD2 (Hs), Smpd2 (Mm), Smpd2 (Rn)
Ensembl ID ENSG00000135587 (Hs), ENSMUSG00000019822 (Mm), ENSRNOG00000000306 (Rn)
UniProtKB AC O60906 (Hs), O70572 (Mm), Q9ET64 (Rn)
EC number
3.1.4.12 sphingomyelin -> ceramide + phosphocholine
Inhibitors
inhibitor A [PMID: 12482429] pKi 5.8 [3] - Bovine

sphingomyelin phosphodiesterase 3 C Show summary »

sphingomyelin phosphodiesterase 4 C Show summary »

sphingomyelin phosphodiesterase acid-like 3A C Show summary »

sphingomyelin phosphodiesterase acid-like 3B C Show summary »

References

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How to cite this family page

Database page citation (select format):

Concise Guide to PHARMACOLOGY citation:

Alexander SP, Fabbro D, Kelly E, Mathie A, Peters JA, Veale EL et al. (2021) THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: Enzymes. Br J Pharmacol. 178 Suppl 1:S313-S411.