Type IX RTKs: MuSK | Catalytic receptors | IUPHAR/BPS Guide to PHARMACOLOGY

Type IX RTKs: MuSK C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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The muscle-specific kinase MuSK is associated with the formation and organisation of the neuromuscular junction from the skeletal muscle side. Agrin (AGRN, O00468) forms a complex with low-density lipoprotein receptor-related protein 4 (LRP4, O75096) to activate MuSK [1].

Receptors

MuSK (muscle associated receptor tyrosine kinase) C Show summary »« Hide summary More detailed page go icon to follow link

Target Id

1847

Nomenclature

muscle associated receptor tyrosine kinase

Common abbreviation

MuSK

Previous and unofficial names

Nsk1 | muscle specific kinase (neural fold/somite kinase 1) | muscle-specific tyrosine protein kinase receptor | MDK4 | Nsk2 | Nsk3 | muscle, skeletal, receptor tyrosine kinase | muscle

Genes

MUSK (Hs), Musk (Mm), Musk (Rn)

Ensembl ID

ENSG00000030304 (Hs), ENSMUSG00000057280 (Mm), ENSRNOG00000033567 (Rn)

UniProtKB AC

O15146 (Hs), Q61006 (Mm), Q62838 (Rn)

EC number

2.7.10.1

Comments

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References

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How to cite this family page

Database page citation:

Type IX RTKs: MuSK. Accessed on 10/11/2024. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=793.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Mathie AA, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Davies JA et al. (2023) The Concise Guide to PHARMACOLOGY 2023/24: Catalytic receptors. Br J Pharmacol. 180 Suppl 2:S241-288.