Top ▲

2.1.1.- Methyltransferases

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Enzymes

3181
Click here for help

TYMS (thymidylate synthetase) C Show summary » More detailed page go icon to follow link

DNA methyltransferase 1 Show summary » More detailed page go icon to follow link

DNA (cytosine-5-)-methyltransferase 3α Show summary » More detailed page go icon to follow link

methyltransferase 3, N6-adenosine-methyltransferase complex catalytic subunit Show summary »


Target Id 3181
Nomenclature methyltransferase 3, N6-adenosine-methyltransferase complex catalytic subunit
Previous and unofficial names methyltransferase-like 3 | methyltransferase 3 | methyltransferase like 3 | mRNA (2'-O-methyladenosine-N6-)-methyltransferase | N6-adenosine-methyltransferase 70 kDa subunit
Genes METTL3 (Hs), Mettl3 (Mm), Mettl3 (Rn)
Ensembl ID ENSG00000165819 (Hs), ENSMUSG00000022160 (Mm), ENSRNOG00000013111 (Rn)
UniProtKB AC Q86U44 (Hs), Q8C3P7 (Mm)
Ligands
WD6305 (Binding) (PROTAC) [4]
Inhibitors
UZH2 pIC50 8.3 [3]
STC-15 pIC50 8.2 [2]
Selective inhibitors
STM2457 pIC50 7.8 [11]
Comment Catalytic subunit of the METTL3-METTL14 methyltransferase complex that 'writes' methyl marks onto adenine residues in mRNA [7,10]. METTL3 has been linked to the initiation and maintenance of cancer [9,13], and is a target for selective drug-like inhibitor development [1,11].

nicotinamide N-methyltransferase Show summary »

Further reading

Click here for help

Show »

References

Click here for help

Show »

How to cite this family page

Database page citation:

2.1.1.- Methyltransferases. Accessed on 22/05/2024. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=843.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Mathie AA, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Davies JA et al. (2023) The Concise Guide to PHARMACOLOGY 2023/24: Enzymes. Br J Pharmacol. 180 Suppl 2:S289-373.