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2.1.1.- Methyltransferases

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Enzymes

3205
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TYMS (thymidylate synthetase) C Show summary » More detailed page go icon to follow link

DNA methyltransferase 1 Show summary » More detailed page go icon to follow link

DNA (cytosine-5-)-methyltransferase 3α Show summary » More detailed page go icon to follow link

methyltransferase 3, N6-adenosine-methyltransferase complex catalytic subunit Show summary »

nicotinamide N-methyltransferase Show summary »


Target Id 3205
Nomenclature nicotinamide N-methyltransferase
Genes NNMT (Hs)
Ensembl ID ENSG00000166741 (Hs)
UniProtKB AC P40261 (Hs)
EC number
2.1.1.1
Inhibitors
NNMT inhibitor 14 [PMID: 35904556] pIC50 9.0 [12], 6.4 [12]
Comment NNMT is a ubiquitously expressed intracellular enzyme that catalyses the methylation of nicotinamide (N-methylation). The reaction uses S-adenosyl methionine as the methyl donor. The association of NNMT overexpression with human diseases has led to the search for selective, small molecule NNMT inhibitors [6,8,12].

Further reading

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References

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How to cite this family page

Database page citation:

2.1.1.- Methyltransferases. Accessed on 14/06/2024. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=843.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Mathie AA, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Davies JA et al. (2023) The Concise Guide to PHARMACOLOGY 2023/24: Enzymes. Br J Pharmacol. 180 Suppl 2:S289-373.