Top ▲
GtoPdb is requesting financial support from commercial users. Please see our sustainability page for more information.
Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).
« Hide
More detailed introduction
Retinoic acid receptor-related orphan receptors (ROR, nomenclature as agreed by the NC-IUPHAR Subcommittee on Nuclear Hormone Receptors [1-2]) have yet to be assigned a definitive endogenous ligand, although RORα may be synthesized with a ‘captured’ agonist such as cholesterol [6-7].
RAR-related orphan receptor-α / NR1F1
C
Show summary »
More detailed page |
RAR-related orphan receptor-β / NR1F2
C
Show summary »
More detailed page |
RAR-related orphan receptor-γ / NR1F3
C
Show summary »
More detailed page |
Database page citation (select format):
Concise Guide to PHARMACOLOGY citation:
Alexander SPH, Cidlowski JA, Kelly E, Mathie AA, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Davies JA et al. (2023) The Concise Guide to PHARMACOLOGY 2023/24: Nuclear hormone receptors. Br J Pharmacol. 180 Suppl 2:S223-240.
Tretinoin shows selectivity for RORβ within the ROR family [9]. RORα has been suggested to be a nuclear receptor responding to melatonin [11].