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Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).
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More detailed introduction
Retinoic acid receptor-related orphan receptors (ROR, nomenclature as agreed by the NC-IUPHAR Subcommittee on Nuclear Hormone Receptors [1-2]) have yet to be assigned a definitive endogenous ligand, although RORα may be synthesized with a ‘captured’ agonist such as cholesterol [6-7].
RAR-related orphan receptor-α / NR1F1
C
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RAR-related orphan receptor-β / NR1F2
C
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RAR-related orphan receptor-γ / NR1F3
C
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Database page citation (select format):
Concise Guide to PHARMACOLOGY citation:
Alexander SP, Cidlowski JA, Kelly E, Mathie A, Peters JA, Veale EL et al. (2021) THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: Nuclear hormone receptors. Br J Pharmacol. 178 Suppl 1:S246-S263.
Tretinoin shows selectivity for RORβ within the ROR family [9]. RORα has been suggested to be a nuclear receptor responding to melatonin [11].